Combined Photodynamic and Pulsed Dye Laser Treatment of Port Wine Stains
Information source: University of California, Irvine
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Port Wine Stains
Intervention: Combine photodynamic therapy and Pulsed Dye Laser (Procedure)
Phase: Phase 1
Status: Enrolling by invitation
Sponsored by: University of California, Irvine
Official(s) and/or principal investigator(s):
Kristen Kelly, M.D, Principal Investigator, Affiliation: Beckman Laser Institute Medical Clinic
This research study designed to determine the effect on port wine stains (PWS) of liposomal
BPD-MA termed verteporfin (distributed for medical indications asVisudyne by QLT, Inc.,
Vancouver, Canada) by intravenous (IV) infusion for photodynamic therapy (PDT) or combined
PDT and pulsed dye laser (PDL) therapy (PDT + PDL). The standard treatment for PWS is PDL
alone. This lightens some PWS but many lesions are not completely removed.
PDT uses a medication and light together to cause injury to a target. The medication is
given and then light is directed at the desired area of treatment to achieve an effect. PDT
has been used to treat some skin conditions including pre-cancers and skin cancers. Using
PDT or PDT immediately followed by PDL therapy may improve PWS lightening. At this time,
both PDT and PDT + PDL therapy for treatment of PWS is investigational. The type and amount
of medication and light which may be used to treat PWS is not known, and is likely to be
different than those used for other PDT treatments.
Official title: Combined Photodynamic and Pulsed Dye Laser Treatment of Port Wine Stains
Study design: Treatment, Non-Randomized, Open Label, Dose Comparison, Single Group Assignment, Safety/Efficacy Study
Primary outcome: Combined sub-threshold photodynamic and pulsed dye laser therapy can be used to safely achieve improved PWS lesion lightening as compared to either sub-threshold photodynamic therapy or pulsed dye laser therapy alone.
Procedures will be performed at the Surgery Laser Clinic at the Beckman Laser Institute at
the University of California Irvine.
At an initial visit, a brief history and physical will be performed.
The history will include: 1) previous treatment to my PWS; 2) current medications; 3) history
of light sensitivity; 4) risk of pregnancy and use of birth control if a female of
The physical will include: 1) measurement and evaluation of PWS; 2) measurement of blood
pressure, blood cell count, general chemistries (including liver function tests) and ANA,
which might indicate an increased sensitivity to light.
On the day of treatment, the same brief physical and history will be repeated. A urine
pregnancy test will be performed if a female of childbearing age.
Four circular test sites of PWS will be selected. One test site will receive no treatment.
The second test sites will be treated with the pulsed dye laser at standard setting and
protective eyeglasses to shield the eyes during the laser treatment.
For two additional test spots, the photodynamic therapy (PDT)verteporfin by intravenous over
a 10-minute period. After receiving the verteporfin, the skin and eyes will be sensitive to
light for the next 5 days. The light sensitive protection precautions will be instructed.
optical Doppler tomography unit(ODT) measurements, similar to shining a flash light to PWS
and measuring the light response,which provide information about how blood is flowing through
Photographs and light measurements will be taken follow-up visits at 1 day, 3 days, 1, 2, 4,
8 and 12 weeks after the study treatment, at these visits blood may also be drawn at these
follow-up visits to check for blood substances that promote blood vessel formation.
At the end of the study, blood tests will be drawn to assess cell count and general
Minimum age: 18 Years.
Maximum age: N/A.
- Adult 18 years and older
- Have a PWS on an area other than the face
- a negative pregnancy test and non pregnant or nursing
- under 18 years of age
- have an allergy to verteporfin, porfimer sodium or other porphyrins
- have a history of porphyria (a disease that can cause sensitivity to light)
- have had treatment to the PWS test sites in the last 8 weeks
- have an active uncontrolled infection or other significant disease
- currently using medications that will make sensitive to light such as tetracyclines,
sulfonamides, phenothiazines, sulfonylurea hypoglycemic agents, thiazide diuretics and
- currently using medications that increase bleeding including aspirin, coumadin or
non-steroidal anti-inflammatory drugs.
- have very dark skin which sensitive to laser treatment
- have a positive ANA (lab tests which indicates sensitive to light)
Locations and Contacts
Beckman Laser Medical Clinic,University, Irvine, California 02612, United States
Starting date: August 2005
Ending date: July 2012
Last updated: May 22, 2008