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Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression

Information source: Hillerod Hospital, Denmark
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Major Depression

Intervention: Pindolol and venlafaxin (Drug)

Phase: N/A

Status: Terminated

Sponsored by: Hillerod Hospital, Denmark

Official(s) and/or principal investigator(s):
Per Bech, Professor, Study Chair, Affiliation: Psychiatric Research Unit, Hillerod Hospital


This study investigates the hypothesis that pindolol can accelerate the response to antidepressants in patients with major depression treated with venlafaxine.

Clinical Details

Official title: A Short Term Double Blind Randomised Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: Hamilton Depression Rating Scale scores

Secondary outcome: Preskorn scores

Detailed description: Antidepressant therapy has a delayed onset of action of 4-6 weeks. Pindolol has in some studies shown an accelerating effect. In this study we investigate the effect of 20 mg of pindolol retarded formulation in combination with Venlafaxine compared to placebo Pindolol and Venlafaxine for a duration of 19 days. Effect is measured by the Hamilton Depression rating Scale and the Preskorn Scale (self-rating).


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Major depression

Exclusion Criteria:

- Allergy towards pindolol, venlafaxine or other tablet constituents

- Liver or kidney impairment

- Diabetics

- Age below 18 years

- Severe cardiac disease

- Asthma.

Locations and Contacts

Psychiatric Research Unit, Hillerod Hospital, Hillerod 3400, Denmark
Additional Information

Starting date: August 2002
Last updated: December 20, 2007

Page last updated: August 23, 2015

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