Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression
Information source: Hillerod Hospital, Denmark
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Major Depression
Intervention: Pindolol and venlafaxin (Drug)
Phase: N/A
Status: Terminated
Sponsored by: Hillerod Hospital, Denmark Official(s) and/or principal investigator(s):
Per Bech, Professor, Study Chair, Affiliation: Psychiatric Research Unit, Hillerod Hospital
Summary
This study investigates the hypothesis that pindolol can accelerate the response to
antidepressants in patients with major depression treated with venlafaxine.
Clinical Details
Official title: A Short Term Double Blind Randomised Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Primary outcome: Hamilton Depression Rating Scale scores
Secondary outcome: Preskorn scores
Detailed description:
Antidepressant therapy has a delayed onset of action of 4-6 weeks. Pindolol has in some
studies shown an accelerating effect. In this study we investigate the effect of 20 mg of
pindolol retarded formulation in combination with Venlafaxine compared to placebo Pindolol
and Venlafaxine for a duration of 19 days.
Effect is measured by the Hamilton Depression rating Scale and the Preskorn Scale
(self-rating).
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Major depression
Exclusion Criteria:
- Allergy towards pindolol, venlafaxine or other tablet constituents
- Liver or kidney impairment
- Diabetics
- Age below 18 years
- Severe cardiac disease
- Asthma.
Locations and Contacts
Psychiatric Research Unit, Hillerod Hospital, Hillerod 3400, Denmark
Additional Information
Starting date: August 2002
Last updated: December 20, 2007
|
