Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia
Information source: Radboud University
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Preeclampsia
Intervention: alpha methyldopa (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Radboud University Official(s) and/or principal investigator(s):
Ineke Krabbendam, MD, Principal Investigator, Affiliation: Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre
Overall contact:
M.E.A Spaanderman, MD, PhD, Phone: +31 24 36 13401, Email: m.spaanderman@obgyn.umcn.nl
Summary
A history of preeclampsia is associated with a low plasma volume and higher sympathetic
activity. Methyldopa will suppress sympathetic activity to normal values. In this study, the
researchers will test that effect on the total cardiovascular balance.
Clinical Details
Official title: Cardiovascular Performance and Autonomic Reactivity in Formerly Preeclamptic Women With a Contracted Plasma Volume (CAPACITY Trial)
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Diagnostic
Primary outcome: normalized plasma volume
Secondary outcome: increased orthostatic tolerancenormalized cardiovascular balance venous capacitance
Detailed description:
This is a randomized double-blind placebo controlled cross-over study in formerly
preeclamptic women with a contracted plasma volume. The researchers will test the effect of
methyldopa on the cardiovascular balance and orthostatic tolerance in women with a history
of preeclampsia and healthy controls.
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- Primiparous
- History of preeclampsia
- Low plasma volume
Exclusion Criteria:
- Thrombophilia
- Hypertension
- Auto-immune disorder
- Insulin dependent diabetes mellitus
Locations and Contacts
M.E.A Spaanderman, MD, PhD, Phone: +31 24 36 13401, Email: m.spaanderman@obgyn.umcn.nl
Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; Recruiting
Additional Information
Starting date: September 2005
Last updated: June 7, 2010
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