Observational Longitudinal Study in Children Affected by Idiopathic Growth Hormone Deficiency (GHD)

Condition(s) targeted: Growth Hormone Deficiency

Intervention: Growth Hormone-Releasing Hormone (Drug)

Phase: N/A

Status: Completed

Sponsored by: Stefania La Grutta, MD

The aim of this study is to assess the developmental patterns of lung function in children affected by growth hormone deficiency after one year of GH therapy. The assessment by specific questionnaires of quality of life and of parental stress index. Parameters will be evaluated at the time of the diagnosis and after 12 months of GH therapy.

Official title: Observational Longitudinal Study in Children Affected by Idiopathic Growth Hormone Deficiency (GHD): Lung Function Parameters Assessment; Quality of Life Assessment; Stress Parenting Assessment (Pneumo GHD)

Study design: Observational Model: Case-Only, Time Perspective: Prospective

Primary outcome: Assessment of the developmental patterns of lung function before and after GH by spirometry

Detailed description: Observational longitudinal study in children affected by idiopathic growth hormone deficiency (GHD): lung function parameters assessment; quality of life assessment; stress parenting assessment (Pneumo GHD). The aim of this study is to assess the developmental patterns of lung function in children affected by growth hormone deficiency after one year of GH therapy. The assessment by specific questionnaires of quality of life and of parental stress index. Parameters will be evaluated at the time of the diagnosis and after 12 months of GH therapy.

Minimum age: 5 Years. Maximum age: 15 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- GH deficiency

Exclusion Criteria:

- Respiratory infections 4 weeks before the recruitment

- Children with autoimmune diseases

- Therapy with drugs able to modify the lung function

Starting date: January 2014
Last updated: July 22, 2015