DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Slowed Carboplatin Infusion for Ovarian Cancer Patients Receiving Carboplatin Re-Treatment

Information source: Massachusetts General Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Recurrent Ovarian Cancer; Platinum Sensitive Ovarian Cancer

Intervention: Carboplatin (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Massachusetts General Hospital

Official(s) and/or principal investigator(s):
Aleena Banerji, MD, Principal Investigator, Affiliation: Massachusetts General Hospital

Overall contact:
Aleena Banerji, MD, Phone: (617) 726-3850, Email: tlax@partners.org

Summary

This is a research study to determine if administering carboplatin at a slower rate when re-treating recurrent ovarian cancer patients prior to the development of a hypersensitivity reaction will decrease the frequency and severity of future hypersensitivity reactions.

Clinical Details

Official title: Slowed Carboplatin Infusion for Ovarian Cancer Patients Receiving Carboplatin Re-Treatment

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Primary outcome:

To determine the frequency of carboplatin infusion reactions using a slowed carboplatin infusion program

To characterize the nature and symptoms of carboplatin reactions associated with the slowed infusion protocol.

Detailed description: For women with recurrent ovarian cancer, re-treatment with carboplatin is frequently recommended. However, carboplatin re-treatment can result in an allergic or allergic-like reaction called a hypersensitivity reaction. Symptoms of a hypersensitivity reaction can include, but are not limited to itching, rash, swelling of the lips, tongue, or throat, chest pain, chest tightness, shortness of breath, wheezing, abdominal pain, nausea, vomiting, diarrhea, palpitations, dizziness, confusion, and low pressure. Hypersensitivity reactions occur in 20-40% of women with recurrent ovarian cancer who are re-treated with carboplatin. At least half of the hypersensitivity reactions are described as moderately severe with symptoms of generalized rash, wheezing, facial swelling, difficulty breathing/shortness of breath, and hypotension (low blood pressure). Patients who suffer from a hypersensitivity reaction while receiving carboplatin and require additional therapy may receive future carboplatin infusions utilizing a "desensitization" technique. A desensitization is when carboplatin is administered in slowly increasing amounts as an inpatient under the direction of the department of Allergy Immunology at Massachusetts General Hospital. A desensitization allows patient to safely receive carboplatin, but requires an inpatient hospitalization, which may be of significant inconvenience to some patients. As part of this study, the participant will continue to receive carboplatin as part of their standard therapy. The change would be instead of carboplatin being administered over a 30 minute period, the carboplatin be administered intravenously according to the following schedule:

- First hour - Administer 1 percent of total dose

- Second hour - Administer 9 percent

- Third hour - Administer 90 percent

Standard pre-medications will be administered immediately prior to the carboplatin infusion which will include of 20 mg of dexamethasone, 50mg of diphenhydramine, and famotidine 20 mg. The participant's medical record will also be reviewed to evaluate whether age, cancer stage/grade, number of previous carboplatin cycles, accompanying agents, and/or medical conditions have an effect on hypersensitivity reactions. The participant will also be asked to fill out a short optional form regarding race and ethnicity to evaluate whether or not these factors contribute to hypersensitivity reactions. If the participant experiences a hypersensitivity reaction, the study protocol will be discontinued. A standard blood draw for a tryptase (a blood test for an allergic reaction) will be obtained at the time of the reaction along with other discretionary laboratories recommended by your oncologist. The participant will then be referred to the Allergy Immunology Department if carboplatin is determined to be necessary for future treatment.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Female.

Criteria:

Inclusion Criteria:

- Participants must have histologically or cytologically confirmed ovarian cancers for

which carboplatin is an acceptable treatment option. In addition, participants must be candidates for systemic chemotherapy as determined by their treating physician.

- Participants must have received a carboplatin-containing regimen at initial

diagnosis. Retreatment is permitted in second or greater line with carboplatin-based chemotherapy.

- Age ≥ 18 years of age

- Eastern Cooperative Oncology Group performance status <2 (see Appendix A).

- Women of childbearing potential must have a negative serum pregnancy test within 72

hours prior to initiating chemotherapy on trial and must agree to practice an effective method of birth control, such as an intrauterine device, tubal ligation, or oral contraceptives, during the study and for six months after their last treatment. Women should not breast-feed while on this study

- Ability to understand and the willingness to sign a written informed consent document

- Patients must be willing to comply with study design and requirements for

participating on the study.

- Laboratory Criteria for eligibility The following are laboratory criteria for

baseline absolute neutrophil count, platelet count, and creatinine for inclusion on this study. Exclusion Criteria:

- Participants who exhibit any of the following conditions at screening will not be

eligible for admission into the study.

- History of allergic reactions attributed to compounds of similar chemical or biologic

composition to carboplatin.

- Uncontrolled intercurrent illness including, but not limited to ongoing or active

infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Locations and Contacts

Aleena Banerji, MD, Phone: (617) 726-3850, Email: tlax@partners.org

Massachusetts General Hospital, Boston, Massachusetts 02215, United States; Recruiting
Aleena Banerji, MD, Phone: 617-726-3850, Email: abanerji@partners.org
Timothy Lax, MD, Phone: (617) 726-3850, Email: tlax@partners.org
Aleena Banerji, MD, Principal Investigator
Additional Information

Starting date: January 2014
Last updated: September 15, 2014

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017