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Effect of Epinephrine on Systemic Absorption of Mepivacaine in Uremic Patients

Information source: Rigshospitalet, Denmark
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Renal Insufficiency, Chronic

Intervention: Mepivacaine with epinephrine (Drug); Plain mepivacaine (Drug)

Phase: N/A

Status: Terminated

Sponsored by: Rigshospitalet, Denmark

Official(s) and/or principal investigator(s):
Robertas Martusevicius, MD, Principal Investigator, Affiliation: Rigshospitalet, Denmark

Summary

The aim of this study is to determine the effect of epinephrine on systemic absorption of local anaesthetic mepivacaine administered for brachial plexus block in uremic patients scheduled for creation or repair of an arteriovenous fistula. Furthermore, an impact of epinephrine on the central circulation and peripheral tissue oxygenation will be evaluated.

Clinical Details

Official title: Effect of Epinephrine on Systemic Absorption of Mepivacaine Administered for Brachial Plexus Block in Patients With Chronic Renal Insufficiency

Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Primary outcome: Plasma concentration of mepivacaine

Secondary outcome:

Central circulation

Peripheral tissue oxygenation

Cardiotoxicity of local anesthetic

Neurotoxicity of local anesthetic

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- patient acceptance of regional anaesthesia

Exclusion Criteria:

- peripheral arteriosclerosis

- diabetes mellitus

- bleeding disorder

- infection at the puncture site

- allergy to mepivacaine

- pregnancy

Locations and Contacts

Rigshospitalet, Copenhagen 2100, Denmark
Additional Information

Information about Mepivacaine from Danish Medicines Agency (in Danish)

Related publications:

McEllistrem RF, Schell J, O'Malley K, O'Toole D, Cunningham AJ. Interscalene brachial plexus blockade with lidocaine in chronic renal failure--a pharmacokinetic study. Can J Anaesth. 1989 Jan;36(1):59-63.

Norio K, Mäkisalo H, Isoniemi H, Groop PH, Pere P, Lindgren L. Are diabetic patients in danger at renal transplantation? An invasive perioperative study. Eur J Anaesthesiol. 2000 Dec;17(12):729-36.

Niemi G. Advantages and disadvantages of adrenaline in regional anaesthesia. Best Pract Res Clin Anaesthesiol. 2005 Jun;19(2):229-45. Review.

Rosenberg PH, Veering BT, Urmey WF. Maximum recommended doses of local anesthetics: a multifactorial concept. Reg Anesth Pain Med. 2004 Nov-Dec;29(6):564-75; discussion 524. Review.

Starting date: September 2012
Last updated: April 15, 2014

Page last updated: August 23, 2015

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