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A Study to Compare the Pharmacokinetics and Pharmacodynamics of LY2963016 to Lantus in Healthy Participants

Information source: Eli Lilly and Company
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Diabetes Mellitus

Intervention: LY2963016 (Drug); Lantus (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: Eli Lilly and Company

Official(s) and/or principal investigator(s):
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST), Study Director, Affiliation: Eli Lilly and Company

Summary

The purposes of this study are to determine the pharmacokinetics and pharmacodynamics of LY2963016 compared to those of basal insulin. The study will also gather information on the safety and tolerability of LY2963016 in healthy participants. Each study period will be approximately 8. 5 days (1. 5 days for treatment and 7 day washout period). There are 4 study periods.

Clinical Details

Official title: Bioequivalence Study Comparing the Pharmacokinetics and Pharmacodynamics of LY2963016 With Insulin Glargine in Healthy Volunteers

Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Primary outcome:

Pharmacokinetics: Area Under the Concentration-Time Curve From Time Zero to 24 Hours [AUC(0-24)] of LY2963016 and Lantus

Pharmacokinetics: Maximum Plasma Concentration (Cmax) of LY2963016 and Lantus

Secondary outcome:

Maximum Glucose Infusion Rate (Rmax)

Total Amount of Glucose Infused (Gtot) Over the Duration of Clamp Procedure

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- are overtly healthy males or females, as determined by medical history and physical

examination

- male participants: agree to use a reliable method of birth control during the

study.

- female participants of child-bearing potential must test negative for pregnancy

at the time of enrollment and agree to either abstain from sexual activity or to use a medically accepted means of contraception when engaging in sexual intercourse throughout the study, or female participants not of child-bearing potential due to surgical sterilization or menopause

- have a body weight of at least 55 kilograms (kg), and body mass index (BMI) of 18. 5

to 32. 0 kilograms/square meter (kg/m²)

- have clinical laboratory test results within normal reference range for the

population

- have venous access sufficient to allow for blood sampling

- are reliable and willing to make themselves available for the duration of the study

and are willing to follow study procedures

- have given written informed consent

- participants should have a normal oral glucose tolerance test

Exclusion Criteria:

- are currently enrolled in, have completed or discontinued within the last 30 days

from, a clinical trial involving an investigational product other than the investigational product used in this study; or are concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study

- have known allergies to heparin, insulin glargine, related compounds or any

components of the formulation

- are persons who have previously received the investigational product in this study,

have completed or withdrawn from this study or any other study investigating LY2963016

- have an abnormality in the 12-lead electrocardiogram (ECG) that, in the opinion of

the investigator, increases the risks associated with participating in the study

- have an abnormal blood pressure as determined by the investigator

- have a significant history or presence of cardiovascular, respiratory, hepatic,

renal, gastrointestinal, endocrine, haematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the study medication

- show evidence of significant active neuropsychiatric disease

- regularly use known drugs of abuse and/or show positive findings on urinary drug

screening

- show evidence of human immunodeficiency virus (HIV) infection and/or positive human

HIV antibodies

- show evidence of hepatitis C and/or positive hepatitis C antibody

- show evidence of hepatitis B and/or positive hepatitis B surface antigen

- are women with a positive pregnancy test or women who are lactating

- intend to use over-the-counter or prescription medication

- have donated blood of more than 500 milliliters (mL) within the last 56 days before

dosing of Period 1

- have an average weekly alcohol intake that exceeds 21 units per week (males) and 14

units per week (females), or are unwilling to stop alcohol consumption for 24 hours before dosing and throughout the duration of each study period

- smoke more than 10 cigarettes (or equivalent other tobacco products) per day

- have a fasting blood glucose > 5. 5 millimoles/Liter (mmol/L) [>99

milligrams/deciliter (mg/dL)]at screening

- have a positive test for anti-LY2963016 or anti-glargine antibodies

Locations and Contacts

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Bloemfontein 9301, South Africa
Additional Information

Starting date: November 2011
Last updated: October 3, 2014

Page last updated: August 23, 2015

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