DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet

Information source: Georgetown University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Salt-sensitive Hypertension

Intervention: Fenoldopam (Drug)

Phase: N/A

Status: Completed

Sponsored by: Georgetown University

Official(s) and/or principal investigator(s):
Aruna R Natarajan, MD, PhD, Principal Investigator, Affiliation: Georgetown University Hospital
Pedro A Jose, MD, PhD, Study Director, Affiliation: Georgetown University/ George Washington University

Summary

The kidney plays a crucial role in maintaining salt balance by two opposing physiological mechanisms: the renal dopaminergic system which enhances salt excretion and the renin-angiotensin system (RAS) which causes salt retention. Salt-sensitive hypertension occurs when this balance is altered or abnormal. We hypothesized that this balance is influenced by salt intake: therefore dietary salt affects the natriuretic response to the renal dopaminergic agonist Fenoldopam, and the Angiotensin Converting Enzyme inhibitor, Enalapril. In this trial we study normal salt balance mechanisms in salt resistant adults with normal blood pressure.

Clinical Details

Official title: Paracrine Regulation of Renal Function by Dopamine in Normotensive Humans

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)

Primary outcome: Urinary sodium excretion

Secondary outcome: Renal Plasma Flow

Detailed description: Eight adults of both genders and all races were studied in this double blind placebo controlled cross over study with randomization of the order of interventions. After 5 days each on low salt (about 1 gram/day) and high salt (about 6 grams/day)diet, with a washout period of at least four weeks in between, every subject was treated with Enalapril and Placebo on two consecutive days, followed by a Fenoldopam infusion for three hours, during which natriuresis and renal function testing were performed.

Eligibility

Minimum age: 18 Years. Maximum age: 55 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Volunteers

- Healthy

- Normal Blood Pressure

Exclusion Criteria:

- Renal Impairment

- Obesity

- Salt sensitive increase in blood pressure

Locations and Contacts

Georgetown University Medical Center, Washington, District of Columbia 20007, United States
Additional Information

Starting date: November 2002
Last updated: March 25, 2011

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017