Fluoroquinolone is a one of the most important drugs for treatment of multidrug-resistant TB
(MDR-TB). Among them, levofloxacin and moxifloxacin has been used most widely. However,
there is no study to directly compare the efficacy of levofloxacin and moxifloxacin among
MDR-TB patients. The investigators will compare the efficacy of levofloxacin and
moxifloxacin through a prospective multicenter randomized open label phase III trial.
Inclusion Criteria:
- Patients with multidrug-resistant TB, but sensitive to levofloxacin and moxifloxacin
Exclusion Criteria:
- Achieved negative conversion of M. TB culture before the enrollment
- Positive anti-HIV antibody
- Pregnant women or sexually active women without using proper birth control method
- Serum creatine grater than 2mg/dL, or urine protein greater than 2+
- Serum total bilirubin greater than 2 mg/dL or AST and ALT greater than 1. 5 times of
normal upper limit
- History or current arrhythmia
- Hypersensitivity to levofloxacin, moxifloxacin,or rifabutin
- Should use drug containing metal-ion, warfarin, phenytoin, theophylline, probenecid
regularly
Kangwon National University Hospital, Chuncheon, Korea, Republic of
Daegu Catholic University Medical Center, Daegu, Korea, Republic of
Keimyung University Dongsan Medical Center, Daegu, Korea, Republic of
Chonnam National University Hospital, Gwangju, Korea, Republic of
Gachon University Gil Hospital, Incheon, Korea, Republic of
Gyeongsang National University Hospital, Jinju, Korea, Republic of
Masan Samsung Medical Center, Masan, Korea, Republic of
Inje University Pusan Paik Hospital, Pusan, Korea, Republic of
Pusan National University Hospital, Pusan, Korea, Republic of
Asan Medical Center, Seoul, Korea, Republic of
Chung-Ang University Yong-san Hospital, Seoul, Korea, Republic of
East-West Neo Medical Center, Seoul, Korea, Republic of
Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
Inje University Sanggye Paik Hospital, Seoul, Korea, Republic of
Kangbuk Samsung Medical Center, Seoul, Korea, Republic of
Korea University Anam Hospital, Seoul, Korea, Republic of
Korea University Guro Hospital, Seoul, Korea, Republic of
Korean Institute of Tuberculosis, Seoul, Korea, Republic of
Samsung Medical Center, Seoul, Korea, Republic of
Seoul Medical Center, Seoul, Korea, Republic of
Seoul National University Boramae Medical Center, Seoul, Korea, Republic of
Seoul National University Hospital, Seoul 110-744, Korea, Republic of
Severance Hospital, Seoul, Korea, Republic of
Chungbuk National University Hospital, Cheongju, Chungbuk, Korea, Republic of
Korea University Ansan Hospital, Ansan, Gyeonggi, Korea, Republic of
Catholic University of Korea Bucheon St. Mary's Hospital, Bucheon, Gyeonggi, Korea, Republic of
Bundang CHA Hospital, Bundang, Gyeonggi, Korea, Republic of
Seoul National University Bundang Hospital, Bundang, Gyeonggi, Korea, Republic of
Hallym University Sacred Heart Hospital, Pyeongchon, Gyeonggi, Korea, Republic of
