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Interaction of Apelin and Angiotensin in the Human Forearm Circulation

Information source: University of Edinburgh
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Heart Disease; Vasodilation

Intervention: Angiotensin II (Drug); Noradrenaline infusion (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Edinburgh

Official(s) and/or principal investigator(s):
Gareth D Barnes, MBChB, Principal Investigator, Affiliation: University of Edinburgh


The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease. Apelin has the ability to cause blood vessels to relax, increasing their diameter and hence blood flow down the blood vessel. The researchers wish to investigate the hypothesis that an infusion of apelin will reduce the effects of angiotensin II, which is know to reduce the diameter of blood vessels.

Clinical Details

Official title: Investigating the Interaction of Apelin and Angiotensin II Peripheral Resistance Vessels in Vivo in Man

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Primary outcome: Change in angiotensin II mediated vasoconstriction

Secondary outcome: Changes in relevant neurohumoral hormones in response to apelin infusion


Minimum age: 18 Years. Maximum age: 85 Years. Gender(s): Both.


Inclusion Criteria:

- > 18 years old

- Healthy volunteers

Exclusion Criteria:

- Lack of informed consent

- Age < 18 years,

- Current involvement in other research studies,

- Systolic blood pressure >190 mmHg or <100 mmHg

- Malignant arrhythmias

- Renal or hepatic failure

- Haemodynamically significant aortic stenosis

- Severe or significant co morbidity

- Women of childbearing potential.

- Any regular medication

- Previous history of any cardiovascular disease

Locations and Contacts

Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc, Edinburgh EH16 4SA, United Kingdom
Additional Information

Starting date: May 2009
Last updated: August 9, 2010

Page last updated: August 23, 2015

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