The SPARC trial is designed to compare the combination of the investigational oral cytotoxic
drug, satraplatin, and prednisone, versus prednisone alone as second line chemotherapy in
patients with hormone-refractory prostate cancer (HRPC).
The SPARC trial is intended for patients who have hormone-refractory prostate cancer (HRPC)
and whose disease has progressed after treatment with one chemotherapy regimen. Please refer
to the Eligibility Criteria page for the key inclusion and exclusion criteria.
Satraplatin is a member of the platinum-based class of chemotherapy drugs. Platinum-based
drugs have been clinically proven to be one of the most effective classes of anticancer
therapies. Unlike the currently marketed platinum-based drugs, satraplatin can be given
orally. Satraplatin is also the only platinum-based drug that has demonstrated efficacy
against prostate cancer in a randomized trial.
There are currently no approved chemotherapy drugs for the second line treatment of
hormone-refractory prostate cancer (HRPC). In a preliminary randomized trial conducted in
Europe, the combination of satraplatin and prednisone had superior activity compared to
prednisone alone, for the treatment of HRPC patients who had not previously been treated with
chemotherapy
Hospital Italiano Regional del Sur Dept. Oncology, Bahia Blanca B8001HXM, Argentina
Grupo Plaza Dept. Oncology, Belen de Escobar B1625FWI, Argentina
Caici Dept. Oncology, Rosario S2000DSK, Argentina
Hospital Italiano de Cordoba Dept. Oncology, Cordoba X5004BAL, Argentina
Instituto Quirúrgico del Callao, Buenos Aires C1022AAE, Argentina
Instituto Alexander Fleming, Buenos Aires C1426ANZ, Argentina
Clinical Especializada ISIS, Santa Fe S3000FFU, Argentina
Centro Oncológico LALCEC, Concepcion del Uruguay, Entre Ríos E3260FPB, Argentina
Centro San Roque, San Miguel de Tucumán, Tucumán T4000IAK, Argentina
Unidad Oncologica del Neuquen, Neuquen Q8300HDH, Argentina
Centro Oncologico Rosario, Rosario S2000DSK, Argentina
Institut Jules Bordet Service de Chimiothérapie, Bruxelles B-1000, Belgium
Hopital Erasme, Bruxelles B-1070, Belgium
AZ-VUB, Bruxelles 1090, Belgium
UCLC St. Luc, Bruxelles B-1200, Belgium
Sint Maartenziekenhuis, Kortrijk 8500, Belgium
Clinical Hostpital Rebro Department of Oncology, Zagreb 10000, Croatia
Clinical Hospital Split Department of Oncology and Radiotherapy, Split 21000, Croatia
Hôpital Tenon, Paris 75020, France
CHU de Poitiers, Poitiers 86021, France
Centre Hospitalier Départemental, La Roche Sur Yon 85025, France
CRLC Val d'Aurelle Paul-Lamarque, Montpellier 34298, France
CHU de Bicêtre, Le Kremlin Bicetre 94278, France
Centre Georges François Leclerc, Dijon 21079, France
Institut Bergonié, Bordeaux Cedex 33076, France
CRLC Léon Bérard, Lyon 69373, France
Institut Jean , Service d'Oncologie, Reims 51100, France
Centre Alexis Vautrin, Vandoeuvre Les Nancy 54500, France
Hôpital Saint-Louis: Service de Radiotherapy, Paris 75010, France
Centre Antoine Lacassagne Oncologie medicale, Nice Cedex 2 06189, France
Hôpital de La Tronche - CHU de Grenoble: Departement de cacerologie et d'hematologie, Grenoble Cedex 09 38043, France
Clinique du Mail Service d'Oncologie, Grenoble 38100, France
Centre Eugene Marquis, Rennes Cedex 35042, France
Centre Hospitalier Belfort-Montbeliard, Montbeliard 25209, France
Chu Dupuytren, Limoges 87000, France
Niedergelassener Urologe, Hamburg 22399, Germany
Klinikum rechts der Isar, München 81675, Germany
Klinik Bad Trissel, Oberaudorf 83080, Germany
EuromedClinic, Fürth 90763, Germany
Universitätsklinikum der Carl-Gustav-Carus Universität, Dresden 01307, Germany
Klinikum der medizinischen Fakultät der Martin-Luther-Universität Halle-Wittenberg, Halle 06120, Germany
Diakonissenkrankenhaus Dessau gGmbH, Dessau 06846, Germany
Fach- und Belegarzte fur Urologie, Berlin 14197, Germany
Medizinische Hochschule, Hannover 30625, Germany
Klinikum der Philipps - Universitat Marburg, Marburg 35043, Germany
RWTH Aachen, Aachen 52074, Germany
Vivantes Krankenhaus am Urban, Berlin 10967, Germany
Stadtische Klinicen Frankfurt a.M. Hochst, Frankfurt a.M. Hochst 65929, Germany
Marienhospital II, Herne 44627, Germany
Klinickum der Johannes-Gutenberg Universitat, Mainz 55131, Germany
Universitatklinikum Munster, Munster 48129, Germany
Universitatklinikum Schleswig-Holstein, Lubeck 23538, Germany
Urologische Praxis, Saarbrücken 04416, Germany
St. Margit Hospital, Budapest 1032, Hungary
National Institute of Oncology, Budapest 1122, Hungary
Pecs Medical University, Pecs 7601, Hungary
St. Istvan Hospital, Budapest 1096, Hungary
Rambam Medical Center, Haifa 31096, Israel
Soroka Medical Center, Beerhseva 84101, Israel
Hadassah University, Jerusalem 91120, Israel
Hospital Ein Kerem Asaf Harofeh Medical Center, Zerifin 70300, Israel
A.O. San Camillo-Forlanini, Rome 00152, Italy
Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa 16132, Italy
A.S.O. San Luigi, Orbassano 10043, Italy
Istituto Clinico Humanitas: Dipartimento di Oncologia Medica ed Ematologia, Rozanno (MI) 20089, Italy
Azienda Ospedaliera di Padova, Padova 35128, Italy
Universita degli Studi di Napoli Federico II-Nuovo Policlinico, Napoli 80131, Italy
Streekziekenhuis Koningin : Dept. Urology, Winterswijk 7101 BN, Netherlands
Academisch Ziekenhuis Nijmegen: Urology Department, Nijmegen GA-6525, Netherlands
Academic Hospital of the University of Amsterdam, Amsterdam 1105 AZ, Netherlands
Essalud Dept. Oncology, Jesus Maria 11, Peru
INEN Dept Onco-Hemato, Lima 34, Peru
San Felipe (Oncomedical), Lima 11, Peru
Akademia Medyczna w Lublinie, Lublin 20-954, Poland
Akademia Medyczna w Lodzi, Lodz 93-509, Poland
Akademia Medyczna w Szczecinie, Szczecin 70-111, Poland
Oddzial Chemioterapii, Bialostocki Osrodek Onkologiczny, Bialystok 15-027, Poland
Oddzial Chemioterapii, 4 Wojskowy Szpital Kliniczny, Wroclaw 50-981, Poland
Oddzial Onkologii I Radioterapii, Szpital Morski im. PCK, Gdynia 81-519, Poland
Oddzial Radioterapii, Wielkopolskie Centrum Onkologii - Instytut, Poznan 61-866, Poland
Klinika Nowotworow Ukladu Moczowego, Centrum Onkologii - Instytut, Warszawa 02-781, Poland
N.N Blokchin Cancer Research Centre, Moscow 115478, Russian Federation
Medical Radilogical Research Center of Rams, Obninsk 249036, Russian Federation
Hertzen Research Institute of Oncology, Moscow 125284, Russian Federation
Instituto Valenciano de Oncología: Sevicio de Oncología Médica, Valencia 46009, Spain
Hospital Clínico San Carlos, Sevicio de Oncología Médica, Madrid 28040, Spain
Clinica Universitaria de Navarra, Sevicio de Oncología Médica, Pamplona 31008, Spain
Hospital Universitario Marqués de Valdecilla, Sevicio de Oncología Médica, Santander 39008, Spain
Hospital de la Santa Creu i Sant Pau, Sevicio de Oncología Médica, Barcelona 08025, Spain
Hospital Clinic i Provincial, Sevicio de Oncología Médica, Barcelona 08036, Spain
Hospital Ramon y Cajal, Madrid 20034, Spain
St. Bartholomew's Hospital Dept. of Medical Oncology, London, United Kingdom
Bristol Oncology Centre, Bristol BS2 8 ED, United Kingdom
Guy's hospital, London SE19RT, United Kingdom
CRUK Institute for Cancer Studies, Birmingham B152TT, United Kingdom
Royal Marsden Hospital, Sutton SM25PT, United Kingdom
Northern Centre for Cancer Treatment, Newcastle Upon Tyne NE4 6BE, United Kingdom
Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, United Kingdom
Lister Hospital Department of Urology, Stevenage Hertfordshire SG1 4 AB, United Kingdom
St George's Healthcare Dept of Oncology, Tooting, London SW17 0QT, United Kingdom
Beatson Oncology Center, Glasgow G11 6NT, United Kingdom
Birmingham Hematology and Oncology, Birmingham, Alabama 35235, United States
Birmingham Hematology and Oncology, Birmingham, Alabama 35205, United States
Hematology Oncology Associates, Phoenix, Arizona 85012, United States
Northern AZ Hematology & Oncology Assoc., Sedona, Arizona 86336, United States
Hematology Oncology Physicians/SMO, Tucson, Arizona 85712, United States
Arizona Cancer Center, Tuscon, Arizona 85724, United States
Clinica Oncologica de Excelencia, Capital Federal, Buenos Aires C1405CBA, Argentina
Salisbury Investigaciones Clinicas del Grupo CER S.A., Quilmes, Buenos Aires B1878DVB, Argentina
Hospital General de Agudos E. Tornu, Capital Federal, Buenos Aires C1427ARN, Argentina
Policlinica Bancaria "9 de Julio" Av. Gaona 2197, Capital Federal, Buenos Aires C1416DRJ, Argentina
Hospital Italiano de Buenos Aires, Capital Federal, Buenos Aires C1181ACH, Argentina
Pacific Shores Medical Group, Long Beach, California 90813, United States
Sharp Healthcare - Clinical Oncology Research, San Diego, California 92123, United States
California Cancer Center, Fresno, California 93720, United States
University of California Davis Cancer Center, Division of Hematology-Oncology, Sacramento, California 95817, United States
Division of Hematology - Oncology, Los Angeles, California 90095-7187, United States
Rocky Mountain Cancer Center - Midtown, Denver, Colorado 80218, United States
DeQuattro Community Cancer Center, Manchester, Connecticut 06040, United States
Hartford Hospital, Hartford, Connecticut 06102, United States
Cancer Centers of Florida-Altamonte, Altamonte Springs, Florida 34761, United States
Florida Cancer Institute, New Port Richey, Florida 34655, United States
Ocala Oncology Center, Ocala, Florida 34474, United States
South Florida Oncology & Hematology, Plantation, Florida 33324, United States
Hematology/Oncology Associates of Treasure Coast, Port St. Lucie, Florida 34952, United States
Oncology and Hematology Associates of West Broward P.A., Tamarac, Florida 33321, United States
The Center for Hematology Oncology, Boca Raton, Florida 33486, United States
Hematology/Oncology Group of South Florida, Miami, Florida 33176, United States
Innovative Medical Research of South Florida, Miami Shores, Florida 33179, United States
Northwest Medical Specialists, Niles, Illinois 60714, United States
North Shore Research Association, Skokie, Illinois 60076, United States
Decatur Memorial Hospital, Decatur, Illinois 62526, United States
Central Indiana Cancer Centers, Fishers, Indiana 46227, United States
Indiana Hematology Oncology Consultants, Indianapolis, Indiana 46202, United States
Central Indiana Cancer Centers, Indianapolis, Indiana 46227, United States
Oncology Associates of Cedar Rapids, Cedar Rapids, Iowa 52403, United States
Kansas City Cancer Centers - Southwest, Overland Park, Kansas 66210, United States
LSU Health Science Center, Stanley S. Scott Cancer Center, New Orleans, Louisiana 70112, United States
Louisiana Oncology Associates, Lafayette, Louisiana 70506, United States
Maine Center for Cancer Medicine & Blood Disorders, Scarborough, Maine 04074, United States
Berkshire Hematology Oncology, Pittsfield, Massachusetts 01201, United States
Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, United States
Maplewood Cancer Center, Maplewood, Minnesota 55404, United States
Virginia Piper Cancer Institute, Minneapolis, Minnesota 55407, United States
Hematology/Oncology Consultants, Inc., St. Louis, Missouri 63136, United States
St. Joseph Oncology, Inc., St. Joseph, Missouri 64507, United States
Arch Medical Services, Inc., Washington, Missouri 63090, United States
Missouri Cancer Associates, Columbia, Missouri 65201, United States
Capitol Comprehensive Cancer Care Clinic, Jefferson City, Missouri 65109, United States
Nebraska Methodist Hospital Cancer Center, Omaha, Nebraska 68114, United States
Nevada Cancer Institute, Las Vegas, Nevada 89135, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada 89109, United States
New Hampshire Oncology-Hematology PA, Hooksett, New Hampshire 03106, United States
Veterans Affairs Medical Center, Albuquerque, New Mexico 87108, United States
Hematology Oncology Associates, Albuquerque, New Mexico 87106, United States
The University of New Mexico, Albuquerque, New Mexico 87131-0001, United States
New Mexico Cancer Care Associates, Santa Fe, New Mexico 87505, United States
Lovelace Sandia Health Systems, Albuquerque, New Mexico 87108, United States
Albany Regional Cancer Center, Albany, New York 12208, United States
Interlakes Oncology Hematology, Canandaigua, New York 14623, United States
New York Oncology Hematology, P.C., Albany, New York 12208, United States
Advanced Oncology Associates, Armonk, New York 10504, United States
Roswell Park Cancer Institute, Buffalo, New York 14263, United States
New York Oncology Hematology, Rexford, New York 12148, United States
Columbia Presbyterian Medical Center, New York, New York 10032, United States
VA Medical Center Syracuse, Syracuse, New York 13210, United States
Piedmont Hematology - Oncology, Winston - Salem, North Carolina 27103, United States
Raleigh Hematology Oncology Clinic, Cary, North Carolina 27511, United States
Dayton Oncology Hematology, Kettering, Ohio 45067, United States
Cancer Care Associates, Oklahoma City, Oklahoma 73120, United States
Cancer Care Associates, Tulsa, Oklahoma 74136, United States
Willamette Valley Cancer Center, Eugene, Oregon 97401, United States
Hematology and Oncology Associates of Northeastern PA / PC, Dunmore, Pennsylvania 18512, United States
University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania 19104, United States
University of Pittsburgh Cancer Institute- Hillman Cancer Center, Pittsburgh, Pennsylvania 15232, United States
Cancer Center of the Carolinas, Seneca, Seneca, South Carolina 29672, United States
Medical University of South Carolina Hollings Cancer Center, Charleston, South Carolina 29425, United States
Charleston Cancer Center, Charleston, South Carolina 29406, United States
The West Clinic, Memphis, Tennessee 38120, United States
Allison Cancer Center, Midland, Texas 79701, United States
El Paso Cancer Treatment Center, El Paso, Texas 79915, United States
Hematology Oncology Associates of South Texas, San Antonio, Texas 78229, United States
Lake Vista Cancer Center, Lewisville, Texas 75067, United States
Longview Cancer Center, Longview, Texas 75601, United States
Mamie McFaddin Ward Cancer Center, Beaumont, Texas 77702, United States
Texas Cancer Center at Medical City, Dallas, Texas 75230, United States
Texas Cancer Center of Mesquite, Mesquite, Texas 75150, United States
Texas Cancer Center, Abilene, Texas 79606, United States
Texas Oncology Cancer Center, Austin, Texas 78731, United States
Texas Oncology, P.A. - Irving, Irving, Texas 75601, United States
Texas Oncology, P.A., Garland, Texas 75042, United States
Texas Oncology, P.A., Ft. Worth, Texas 76104, United States
Waco Cancer Care Research Center, Waco, Texas 76712, United States
The Texas Cancer Center, Dallas, Texas 75237, United States
Tyler Cancer Center, Tyler, Texas 75702, United States
S. Texas Cancer Center, McAllen, Texas 78503, United States
West Texas Cancer Center, Odessa, Texas 79761, United States
Southwest Regional Cancer Center, Austin, Texas 78705, United States
San Antonio Tumor & Blood Clinic, Fredericksburg, Texas 78624, United States
Texas Oncology, P.A. - Deke Slayton Cancer Center, Webster, Texas 77598, United States
Texas Oncology, P.A., Dallas, Texas 75231-1449, United States
El Paso Cancer Treatment Center, El Paso, Texas 79915, United States
Texas Oncology, Arlington, Texas 76012, United States
Texas Onoclogy PA - Bedford, Bedford, Texas 76022, United States
Texas Cancer Center, Denton, Texas 76210, United States
TOPA Sammons Cancer Center, Dallas, Texas 75246, United States
Onc and Hem Associates of SW VA, Inc., Salem, Virginia 24153, United States
Virginia Oncology Associates, Norfolk, Virginia 23501, United States
Cancer Care Northwest-North, Spokane, Washington 99218, United States
Northwest Cancer Specialists, Vancouver, Washington 98684, United States
Puget Sound Cancer Center - Edmonds, Edmonds, Washington 98026, United States
Froedtert Memorial Lutheran Hospital, Milwaukee, Wisconsin 53226, United States
