In-hospital Cardiac Arrest - Dynamics and State Transitions
Information source: St. Olavs Hospital
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Heart Arrest; Cardiopulmonary Resuscitation; Death, Sudden, Cardiac
Intervention: Cardiopulmonary resuscitation (CPR) (Procedure); Epinephrine (Drug); Atropine (Drug); Amiodarone (Drug); External defibrillator (Device)
Phase: N/A
Status: Recruiting
Sponsored by: St. Olavs Hospital Official(s) and/or principal investigator(s):
Eirik Skogvoll, MD, PhD, Study Chair, Affiliation: St. Olavs Hospital
Trond Nordseth, MD, Principal Investigator, Affiliation: St. Olavs Hospital
Overall contact:
Eirik Skogvoll, MD, PhD, Phone: +4772574549, Email: eirik.skogvoll@ntnu.no
Summary
The purpose of this study is to analyse transitions in cardiac rhythm and hemodynamic
variables during resuscitation of patients with in-hospital cardiac arrest.
Clinical Details
Official title: Dynamics and State Transitions During Resuscitation in In-hospital Cardiac Arrest
Study design: Cohort, Prospective
Primary outcome: Survival to discharge
Secondary outcome: Short-term survival
Detailed description:
In-hospital cardiac arrest carries a grave prognosis, with survival to discharge in the
range of 15-20%. Key factors determining outcome include the presenting cardiac rhythm,
aetiology, and early initiation of resuscitation. Some cardiac rhythms benefit from
defibrillation (shockable rhythms). During resuscitation patients may switch between
shockable and non-shockable rhythms, and may show signs of spontaneous circulation
temporarily. Depending on rhythm and according to guidelines, patients receive DC shocks
(defibrillator) and/or i. v. adrenaline, atropine and amiodarone, which may affect
state-transitions. We wish to make statistical analysis (time-series analysis, Markov
modelling) of these state-transitions and variations in hemodynamic variables during
resuscitation, related to CPR interventions and the cause of arrest. The cause of arrest
will be determined based on chart records, interview with staff and autopsy if appropriate.
One hypothesis is that differences in the patterns of state-transitions may reflect
underlying aetiology, which may guide in future decision-making during resuscitation.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients with in-hospital cardiac arrest who are resuscitated
Exclusion Criteria:
- Younger than 18 years old
Locations and Contacts
Eirik Skogvoll, MD, PhD, Phone: +4772574549, Email: eirik.skogvoll@ntnu.no
St.Olavs Hospital, Department of Anesthesia, Trondheim 7014, Norway; Recruiting
Trond Nordseth, MD, Principal Investigator
Daniel Bergum, MD, Sub-Investigator
Additional Information
Related publications: Skogvoll E, Nordseth T. The early minutes of in-hospital cardiac arrest: Shock or CPR? A population based prospective study. Scand J Trauma Resusc Emerg Med. 2008 Sep 22;16(1):11. Skogvoll E, Eftestøl T, Gundersen K, Kvaløy JT, Kramer-Johansen J, Olasveengen TM, Steen PA. Dynamics and state transitions during resuscitation in out-of-hospital cardiac arrest. Resuscitation. 2008 Jul;78(1):30-7. Epub 2008 Apr 10.
Starting date: August 2009
Ending date: June 2014
Last updated: August 10, 2009
|
