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Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema

Information source: Gelb, Arthur F., M.D.
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: COPD; Emphysema

Intervention: tiotropium (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Gelb, Arthur F., M.D.

Official(s) and/or principal investigator(s):
Arthur F Gelb, MD, Principal Investigator, Affiliation: Arthur F Gelb Medical Corporation

Summary

To evaluate if tiotropium (Spiriva)induced bronchodilation of inspiratory capacity in patients with moderate to severe copd subjected to metronome paced hyperventilation induced dynamic hyperinflation is dependent upon the extent of underlying emphysema as determined by high resolution-thin section CT lung.

Clinical Details

Official title: Effectiveness of Tiotropium to Maintain Inspiratory Capacity Against Metronome Paced Hyperventilation Induced Dynamic Hyperinflation in COPD Patients With Lung CT Scored Emphysema

Study design: Observational Model: Case-Crossover, Time Perspective: Retrospective

Primary outcome: Correlate tiotropium induced increase in inspiratory capacity (IC)and FEV 1 with extent of emphysema as scored by lung CT.

Secondary outcome: Correlate decrease in IC and FEV 1 following dynamic hyperinflation with underlying emphysema.

Detailed description: We will analyze post hoc, data that was previously published: Gelb AF et al. Chest 2006;131: 690-695. We have shown that tiotropium increases resting inspiratory capacity thereby providing lung volume protection against metronome paced hyperventilation induced dynamic hyperinflation. End point will be to correlate increase in tiotropium induced FEV 1(L) and inspiratory capacity with extent of underlying emphysema as scored by lung CT ( Gelb AF et al: Chest 1996; 109: 353-359)in 29 patients with COPD. We will also correlate the decrease in inspiratory capacity following metronome paced hyperventilation induced dynamic hyperinflation with extent of lung CT scored emphysema.

Eligibility

Minimum age: 40 Years. Maximum age: 85 Years. Gender(s): Both.

Criteria:

Inclusion Criteria

- moderate to severe copd

Exclusion Criteria

- unable to tolerate tiotropium

- unable to perform metronome paced hyperventilation induced dynamic hyperinflation

Locations and Contacts

Arthur F Gelb Medical Corporation, Lakewood, California 90712, United States
Additional Information

Related publications:

Gelb AF, Taylor CF, McClean PA, Shinar CM, Rodrigues MT, Gutierrez CA, Chapman KR, Zamel N. Tiotropium and simplified detection of dynamic hyperinflation. Chest. 2007 Mar;131(3):690-5.

Gelb AF, Hogg JC, Müller NL, Schein MJ, Kuei J, Tashkin DP, Epstein JD, Kollin J, Green RH, Zamel N, Elliott WM, Hadjiaghai L. Contribution of emphysema and small airways in COPD. Chest. 1996 Feb;109(2):353-9.

Starting date: August 2004
Last updated: August 13, 2008

Page last updated: August 23, 2015

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