Simvatstatin Used to Treat Pulmonary Hypertension

Condition(s) targeted: Hypertension, Pulmonary

Intervention: simvastatin (Drug)

Phase: Phase 1

Status: Not yet recruiting

Sponsored by: Capital Medical University

Official(s) and/or principal investigator(s):
Huili Gan, MD,Ph.D., Study Chair, Affiliation: Beijing Anzehn Hospital

Overall contact:
Huili Gan, MD,Ph.D., Phone: 13001277863, Email: ganhuili@hotmail.com

we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

Official title: the Clinical Research Using Simvastatin as a Medication to Treat Advanced Secondary Pulmonary Hypertension

Study design: Treatment, Randomized, Single Blind (Investigator), Placebo Control, Parallel Assignment

Primary outcome:

the simvastatin can alleviate pulmonary hypertension

pulmonary pressure

Secondary outcome: simvastatin can highten the perioperative and long term survaval rate and the living quality

Detailed description: advanced pulmonary hypertension is refractory to the medication in use nowaday, especially pulmonary hypertension secondary to congenital heart disease or chronic pulmonary embolism. It is revealed that statins may intefere the pathogenisis of the pulmonary hypertension in many key poing, such as improving apotosis or inhiting the proliferation of pulmonary vascular smooth muscle cell. so we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

Minimum age: 12 Years. Maximum age: 70 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- pasp>50mmHg

Exclusion Criteria:

- pasp<50mmhg

Huili Gan, MD,Ph.D., Phone: 13001277863, Email: ganhuili@hotmail.com

Beijing Anzhen Hospital, Beijing 100029, China

Starting date: January 2009
Ending date: January 2012
Last updated: October 1, 2007