Escitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are
selective serotonin reuptake inhibitors (SSRIs) and are used to treat depression in adults.
This study is designed to evaluate the efficacy and safety of a fixed-dose escitalopram
combination relative to its component monotherapies and to placebo in patients with major
depressive disorder.
Inclusion Criteria:
- Patients must meet Diagnostic and Statistical Manual, Fourth Edition (DSM-IV)
diagnostic criteria for Major Depressive Disorder.
- The patient's current depressive episode must be at least 12 weeks in duration.
Exclusion Criteria:
- Women who are pregnant, women who will be breastfeeding during the study, and women of
childbearing potential who are not practicing a reliable method of birth control.
- Patients who currently meet DSM-IV criteria for: a. bipolar disorder; b. schizophrenia
or any psychotic disorder; c. obsessive-compulsive disorder; d. mental retardation or
any pervasive developmental disorder or cognitive disorder.
- Patients who are considered a suicide risk.
- Patients with a history of seizure disorder, or any history of seizure, stroke,
significant head injury, or any other condition that predisposes toward risk of
seizure.
Southwest Health, Ltd, Phoenix, Arizona 85016, United States
Alpine Clinical Research, Boulder, Colorado 80304, United States
Radiant Research, Inc., Denver, Colorado 80212, United States
Clinical Neuroscience Solutions, Inc., Orlando, Florida 32806, United States
Cunningham Clinical Research, LLC, Edwardsville, Illinois 62025, United States
Midwest Center for Neurobiological Medicine, Oakbrook Terrace, Illinois 60181, United States
Capital Clinical Research Associates, Rockville, Maryland 20852, United States
Summit Research Network (Michigan), Inc., Okemos, Michigan 48864, United States
CNS Research Institute, Clementon, New Jersey 08021, United States
Center for Emotional Fitness, Moorestown, New Jersey 08057, United States
Eastside Comprehensive Medical Center, New York, New York 10021, United States
Piedmont Medical Research Associates, Inc., Winston-Salem, North Carolina 27103, United States
Clinical Neuroscience Solutions, Inc., Memphis, Tennessee 38119, United States
Croft Group Research Center, San Antonio, Texas 78229, United States
Claghorn-Lesem Research Clinic, Bellaire, Texas 77401, United States
Dominion Clinical Research, Midlothian, Virginia 23112-3989, United States
Northwest Clinical Research Center, Bellevue, Washington 98004, United States
Summit Research Network (Seattle), LLC, Seattle, Washington 98104, United States
