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Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer

Information source: University of Kentucky
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Active Cocaine Users

Intervention: Cocaine (Drug); Sustained Release d-Amphetamine (Drug)

Phase: Phase 0

Status: Recruiting

Sponsored by: University of Kentucky

Summary

Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate choice self-administration procedures between drug and a non-drug alternative reinforcer presented during maintenance on d-amphetamine, which has been previously shown to reduce cocaine use.

Clinical Details

Study design: Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Basic Science

Primary outcome: Number of Injections of self-administered cocaine

Eligibility

Minimum age: 21 Years. Maximum age: 45 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Recent cocaine use, otherwise healthy

Exclusion Criteria:

- Laboratory results outside of clinically acceptable ranges, history of or current

serious physical or psychiatric disease

Locations and Contacts

Laboratory of Human Behavioral Pharmacology, Lexington, Kentucky 40536-0086, United States; Recruiting
Frances Wagner, RN, Phone: 859-257-5388
Joshua Lile, Ph.D., Principal Investigator
Additional Information

Starting date: February 2015
Last updated: March 3, 2015

Page last updated: August 20, 2015

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