Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer
Information source: University of Kentucky
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Active Cocaine Users
Intervention: Cocaine (Drug); Sustained Release d-Amphetamine (Drug)
Phase: Phase 0
Status: Recruiting
Sponsored by: University of Kentucky
Summary
Cocaine-use disorders continue to be a significant public health concern, yet no effective
medications have been identified. The goal of this study is to establish a research platform
for the development of medications for treatment of cocaine abuse and dependence. This study
will incorporate choice self-administration procedures between drug and a non-drug
alternative reinforcer presented during maintenance on d-amphetamine, which has been
previously shown to reduce cocaine use.
Clinical Details
Study design: Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Basic Science
Primary outcome: Number of Injections of self-administered cocaine
Eligibility
Minimum age: 21 Years.
Maximum age: 45 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Recent cocaine use, otherwise healthy
Exclusion Criteria:
- Laboratory results outside of clinically acceptable ranges, history of or current
serious physical or psychiatric disease
Locations and Contacts
Laboratory of Human Behavioral Pharmacology, Lexington, Kentucky 40536-0086, United States; Recruiting
Frances Wagner, RN, Phone: 859-257-5388
Joshua Lile, Ph.D., Principal Investigator
Additional Information
Starting date: February 2015
Last updated: March 3, 2015
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