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Root Biomodification With Citric Acid and Tetracycline Improves the Outcomes of Root Coverage

Information source: University of Sao Paulo
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Gingival Recession

Intervention: Root conditioning with citric acid+tetracycline solution (Other)

Phase: N/A

Status: Completed

Sponsored by: University of Sao Paulo

Official(s) and/or principal investigator(s):
João Paulo C Barros, Master, Principal Investigator, Affiliation: Graduation student


The aim of this study is to investigate the effects of the application of a citric acid + tetracycline gel solution during 90 or 180 seconds compared to no conditioning in the outcomes of treatment of Miller's class I or II recession defects by subepithelial connective tissue graft.

Clinical Details

Official title: Conditioning of Root Surfaces With Citric Acid and Tetracycline for Different Application Times Improves the Outcomes of Root Coverage by Subepithelial Connective Tissue Graft: a Randomized Clinical Trial.

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: percentage of root coverage (%REC)

Secondary outcome:

reduction in recession height

increase in the width of keratinized gingiva

gain in clinical attachment level

Detailed description: Adult patients showing Miller's class I or II recession defects requiring root coverage were recruited to participate in the study. All patients were submitted to non surgical periodontal therapy consisting of scaling and root planing, prophylaxis, and oral hygiene instruction in order to reduce/eliminate gingival inflammation. After that, patients were randomly allocated to three different treatment groups based on root conditioning: G0- no conditioning; G90- root conditioning for 90 seconds; G180- root conditioning for 180 seconds. Allocation was defined by a software. Root coverage was performed by subepithelial connective tissue graft (SCTG) in all treated sites by the same operator, who performed the indicated root treatment. Periodontal parameters were investigated at baseline and at 1, 3, 6 and 12 months post-operatively by a blinded trained expertise different from operator and included: pocket depth, recession height, clinical attachment level, width of keratinized gingiva, sulcular bleeding index and plaque index. Hypersensitivity at recession sites was also investigated at baseline and at 7 days, 14 days, 1, 3, 6 and 12 months after treatment according to visual analogic scale (VAS).


Minimum age: 20 Years. Maximum age: 60 Years. Gender(s): Both.


Inclusion Criteria:

- presence of Miller's class I or II recession extending 2-5 mm apical to CEJ requiring

root coverage for the following reasons: esthetics, progression of recession or hypersensitivity. Exclusion Criteria:

- smokers;

- pregnants;

- routine use of anti-convulsants, anti-hypertensive or cyclosporine;

- uncontrolled systemic diseases (e. g.: diabetes mellitus);

- systemic conditions that requires antibiotic prophylaxis (e. g.: history of bacterial

endocarditis; rheumatoid arthritis; prosthetic valves);

- antibiotics, steroidal or non-steroidal anti-inflammatory intake in the 6-month

previous period.

Locations and Contacts

School of Dentistry at Bauru- University of São Paulo; Clinics of Periodontics, Bauru, São Paulo 17012-912, Brazil
Additional Information

Starting date: August 2011
Last updated: October 5, 2014

Page last updated: August 23, 2015

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