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Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients

Information source: First Affiliated Hospital Xi'an Jiaotong University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Cognitive Dysfunction

Intervention: dexmedetomidine (Drug); dexmedetomidine (Drug); normal saline (Drug); midazolam,fentanyl,etomidate,Cisatracurium besylate (Drug); cisatracurium besylate,propofol,remifentanil,sevoflurane (Drug)

Phase: Phase 4

Status: Not yet recruiting

Sponsored by: First Affiliated Hospital Xi'an Jiaotong University

Summary

The purpose of this study is to identify the effects of different doses of dexmedetomidine on postoperative cognitive dysfunction in elderly hypertensive patients

Clinical Details

Official title: Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients-A Single Center,Randomized, Double-blinded,Controlled Study

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome:

Change from baseline to postoperation in cognitive function

Change from baseline to postoperation in recent memory

Change from baseline to postoperation in visual space and directional force

Change from baseline to postoperation in attention

Change from baseline to postoperation in pain scores

Change from baseline to postoperation in depression scale

Secondary outcome:

The duration of operation

The blood volume during the operation

The urine volume during operation

The dose of drugs used during operation

Eligibility

Minimum age: 65 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Written informed consent

- Elective gastrointestinal surgery

- American Society of Anesthesiologists class II to III

- Aged between 65 and 80 years old

- Weight between 45 and 75 kilogram,Body Mass Index between 19 and 24 kg. m-2

- With primary hypertension reaching or more than 1 year

- Normal cognitive function,mini-mental state examination more than 27

Exclusion Criteria:

- Severe arrhythmia,atrioventricular block and secondary hypertension

- Liver and kidney dysfunction,pulmonary disease,endocrine disease

- Suspected or confirmed difficult airway

- Any disease or pathologic change will interfere study result

- Inability to exchange with serious visual and hearing impairment

- Long term use of sedative-hypnotic drugs and antidepressant drug

- Addicted to alcohol, tobacco or drug

- Neuromuscular disease

- Suspected of malignant hyperthermia

- Allergic to investigational products or with other contraindication

- Participated in other study within 30 days

Locations and Contacts

Additional Information

Starting date: September 2014
Last updated: August 21, 2014

Page last updated: August 23, 2015

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