Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients
Information source: First Affiliated Hospital Xi'an Jiaotong University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Postoperative Cognitive Dysfunction
Intervention: dexmedetomidine (Drug); dexmedetomidine (Drug); normal saline (Drug); midazolam,fentanyl,etomidate,Cisatracurium besylate (Drug); cisatracurium besylate,propofol,remifentanil,sevoflurane (Drug)
Phase: Phase 4
Status: Not yet recruiting
Sponsored by: First Affiliated Hospital Xi'an Jiaotong University
Summary
The purpose of this study is to identify the effects of different doses of dexmedetomidine
on postoperative cognitive dysfunction in elderly hypertensive patients
Clinical Details
Official title: Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients-A Single Center,Randomized, Double-blinded,Controlled Study
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Primary outcome: Change from baseline to postoperation in cognitive functionChange from baseline to postoperation in recent memory Change from baseline to postoperation in visual space and directional force Change from baseline to postoperation in attention Change from baseline to postoperation in pain scores Change from baseline to postoperation in depression scale
Secondary outcome: The duration of operationThe blood volume during the operation The urine volume during operation The dose of drugs used during operation
Eligibility
Minimum age: 65 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Written informed consent
- Elective gastrointestinal surgery
- American Society of Anesthesiologists class II to III
- Aged between 65 and 80 years old
- Weight between 45 and 75 kilogram,Body Mass Index between 19 and 24 kg. m-2
- With primary hypertension reaching or more than 1 year
- Normal cognitive function,mini-mental state examination more than 27
Exclusion Criteria:
- Severe arrhythmia,atrioventricular block and secondary hypertension
- Liver and kidney dysfunction,pulmonary disease,endocrine disease
- Suspected or confirmed difficult airway
- Any disease or pathologic change will interfere study result
- Inability to exchange with serious visual and hearing impairment
- Long term use of sedative-hypnotic drugs and antidepressant drug
- Addicted to alcohol, tobacco or drug
- Neuromuscular disease
- Suspected of malignant hyperthermia
- Allergic to investigational products or with other contraindication
- Participated in other study within 30 days
Locations and Contacts
Additional Information
Starting date: September 2014
Last updated: August 21, 2014
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