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The Effect of Sevoflurane on Cerebral CO2 Sensitivity and Systemic Arteries

Information source: University of Debrecen
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Sevoflurane Anesthesia

Intervention: Partial pressure of CO2 at the end of an exhaled breath (Procedure); Sevoflurane (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: University of Debrecen

Official(s) and/or principal investigator(s):
Csilla Molnár, MD, PhD, Principal Investigator, Affiliation: University of Debrecen Medical and Health Science Center Department of Anesthesiology and Intensive Care 4032-Debrecen, Nagyerdei krt 98. Hungary Tel/fax: +36-52-255-347



- The purpose of this study is to examine the effect of different carbon-dioxide

concentrations on cerebral CO2 sensitivity and the resistance and stiffness of systemic arteries during anesthesia with sevoflurane. Sevoflurane is a widely and commonly used inhalational anaesthetic, that is mainly used for the maintenance of general anesthesia.

- Changes in the velocity of cerebral blood flow and arterial stiffness due to the

different exhaled carbon-dioxide concentrations will allow us to conclude how sevoflurane affects these parameters during the course of the narcosis. Instruments:

- An ultrasound device called transcranial doppler (TCD) is used to measure the velocity

of blood flow within a main artery located inside the skull.

- A tonometry device named SphygmoCor is used to assess the pressure wave proceeding in

the radial artery, from which the stiffness of the systemic vessels can be concluded. Measurements:

- Examinations with the ultrasound and tonometry devices are carried out once before the

operation, three times during the intervention, with different exhaled CO2 values and once after the operation is completed. Hypothesis:

- Sevoflurane alters cerebral carbon-dioxide sensitivity and the stiffness of systemic


Clinical Details

Official title: The Effect of Sevoflurane on Cerebral Vasoreactivity Ans Systemic Arteries

Study design: Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome: Blood flow velocity in the middle cerebral artery

Secondary outcome:

Arterial wall stiffness of the radial artery

Changes in the central systolic and diastolic blood pressure

Detailed description: Study protocol:

- The study is conducted in four stages: in the first stage, measurements are performed

preoperatively in awake patients. Patients are placed in supine position and mean arterial blood pressure (MAP), heart rate, oxygen saturation are measured. The transcranial doppler (TCD) probe is fixed in place by applying a headband to maintain a constant angle of insonation. Mean blood flow velocity (MBFV) and pulsatility index (PI) in the middle cerebral artery (MCA) are obtained. MCA is insonated through the right temporal window by using pulsed 2 megahertz TCD ultrasound probe. Identification of the MCA is confirmed by using standard criteria, at a depth of 45-55 mm. Cerebral CO2 vasoreactivity is calculated as the percentage change in MBFV or PI for mmHg change in end-tidal CO2 (ETCO2). SphygmoCor is placed on the left radial artery to obtain data about the central aortic blood pressure, augmentation pressure (AP) and augmentation index normalised to a 75 beat per minute heart rate (Alx75). From the derived aortic pulse, calculations can be made, using the area under the systolic and diastolic part of the curve, to determine the heart's ratio of oxygen supply and demand, it is called the subendocardial viability ratio (SEVR). As part of the premedication each patient receives 7. 5 mg midazolam. Anaesthesia is induced using 2 mcg/kg fentanyl followed by 2 mg/kg propofol. Afterwards 0. 6mg/kg rocuronium is given for muscle paralysis and subsequently patients were intubated with a suitable intratracheal tube. After induction of anaesthesia, the patients are placed on a mechanical ventilation system, using a volume-controlled setting with an air and oxygen mixture set to 0. 4 fraction of inspired oxygen (FiO2) , the fresh gas flow rate to 2 l/min and sevoflurane is adjusted to reach a constant 1minimal alveolar concentration (MAC) during examination. Anesthesia is maintained with sevoflurane and on demand fentanyl boluses. Differences in the depth of anesthesia could influence cerebral activity, thereby cerebral metabolism and blood flow. Bispectral index is placed onto every patient in order to assure constant depth of anaesthesia during the intervention. The second series of TCD and SphygmoCor measurements are performed 20 minutes after the respiratory rate is set to maintain end-tidal CO2 at 40 mmHg in order to allow sufficient time for equilibrium to be reached and the effect of drugs used for the induction of anesthesia to be terminated. Subsequently the examinations are repeated twice again at 35 and 30 mmHg ETCO2. The measurements were carried out 5-5 minutes after adjusting the minute ventilation to reach target ETCO2 values. Statistical methods:

- Comparisons between the preoperative and three intraoperative stages of the study are made

using repeated measures ANOVA with the Bonferroni post hoc correction. The relationship between MBFV, PI and ETCO2 is assessed using linear regression, while the connection between SEVR, pulse and Alx75 is calculated with bivariate correlation.


Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.


Inclusion Criteria:

- Above the age 18

- American Society of Anesthesiologists (ASA) physical classification I. or II.

- Patients undergoing elective varicotomy or inguinal hernioplasty in general

anesthesia Exclusion Criteria:

- Patients with cerebral, cardiac or systemic vascular disorders (hypertension,


- Patients receiving medication that affects the blood vessels (antihypertensive,

antidiabetic, antiarrhythmic medications)

Locations and Contacts

University of Debrecen Medical and Health Science Center Department of Anesthesiology and Intensive Care, Debrecen 4032, Hungary
Additional Information

Starting date: November 2012
Last updated: February 3, 2014

Page last updated: August 23, 2015

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