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Methadone in Pediatric Anesthesia

Information source: Washington University School of Medicine
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Anesthesia

Intervention: Methadone (Drug)

Phase: N/A

Status: Completed

Sponsored by: Washington University School of Medicine

Official(s) and/or principal investigator(s):
Evan Kharasch, MD, PhD, Principal Investigator, Affiliation: Washington University School of Medicine


This study will determine the pharmacokinetics of intravenous (IV) methadone in children undergoing surgery.

Clinical Details

Official title: Methadone in Pediatric Anesthesia

Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Determine PKs of IV methadone in children undergoing surgery


Minimum age: 5 Years. Maximum age: 18 Years. Gender(s): Both.


Inclusion Criteria:

- Age 5-18

- Undergoing General anesthesia and surgery with anticipated postoperative inpatient

stay of greater than or equal to 3 days

- Signed, written, informed consent from legal guardians and assent from patient

Exclusion Criteria:

- History of or known liver or kidney disease

Locations and Contacts

Washington University School of Medicine, St. Louis, Missouri 63110, United States
Additional Information

Starting date: May 2009
Last updated: June 2, 2015

Page last updated: August 23, 2015

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