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Assessment of Ventilation-perfusion Abnormalities in Patients With Stable Smoking-related Airways Disease

Information source: Imperial College London
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Chronic Obstructive Pulmonary Disease

Intervention: salbutamol + ipratropium bromide nebules (Drug); nebulized saline (Drug)

Phase: N/A

Status: Terminated

Sponsored by: Imperial College London

Official(s) and/or principal investigator(s):
Philip W Ind, MB BChir MRCP, Principal Investigator, Affiliation: Imperial College Hammersmith

Summary

Subjects undergo history, examination, lung function assessment after informed consent has been obtained. All subjects will undergo ventilation-perfusion scans. If there first scan is normal they will undergo a second and final scan four weeks later. If abnormal they will undergo two further scans with either nebulized bronchodilator or nebulized saline prior to their second and third scans. Each time they will have repeat lung function tests prior to scanning. We will examine the regional changes in ventilation and perfusion and there relationship to lung function.

Clinical Details

Official title: Assessment of Ventilation-perfusion Abnormalities in Patients With Smoking-related Airways Disease in Stable Condition and the Effect of Bronchodilator Therapy

Study design: Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Basic Science

Primary outcome: scan grade

Secondary outcome: lung function

Detailed description: As in Brief description

Eligibility

Minimum age: 35 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- FEV1 < 70% predicted at baseline on spirometry

- significant smoking history or alpha 1 antitrypsin deficiency

- no evidence of current infection or restrictive lung disease

Exclusion Criteria:

- history of other significant respiratory disease

- significant respiratory infection within 6 weeks

- history of significant physical or mental illness rendering them unfit for the study

in the opinion of the investigator

- taken part in any other research within the past 12 months, or received exposure to

ionizing radiation

Locations and Contacts

Imperial College Hammersmith Campus, London W12 0HS, United Kingdom
Additional Information

Starting date: September 2005
Last updated: September 21, 2013

Page last updated: August 23, 2015

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