Assessment of Ventilation-perfusion Abnormalities in Patients With Stable Smoking-related Airways Disease
Information source: Imperial College London
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Chronic Obstructive Pulmonary Disease
Intervention: salbutamol + ipratropium bromide nebules (Drug); nebulized saline (Drug)
Phase: N/A
Status: Terminated
Sponsored by: Imperial College London Official(s) and/or principal investigator(s): Philip W Ind, MB BChir MRCP, Principal Investigator, Affiliation: Imperial College Hammersmith
Summary
Subjects undergo history, examination, lung function assessment after informed consent has
been obtained. All subjects will undergo ventilation-perfusion scans. If there first scan is
normal they will undergo a second and final scan four weeks later. If abnormal they will
undergo two further scans with either nebulized bronchodilator or nebulized saline prior to
their second and third scans. Each time they will have repeat lung function tests prior to
scanning. We will examine the regional changes in ventilation and perfusion and there
relationship to lung function.
Clinical Details
Official title: Assessment of Ventilation-perfusion Abnormalities in Patients With Smoking-related Airways Disease in Stable Condition and the Effect of Bronchodilator Therapy
Study design: Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Basic Science
Primary outcome: scan grade
Secondary outcome: lung function
Detailed description:
As in Brief description
Eligibility
Minimum age: 35 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- FEV1 < 70% predicted at baseline on spirometry
- significant smoking history or alpha 1 antitrypsin deficiency
- no evidence of current infection or restrictive lung disease
Exclusion Criteria:
- history of other significant respiratory disease
- significant respiratory infection within 6 weeks
- history of significant physical or mental illness rendering them unfit for the study
in the opinion of the investigator
- taken part in any other research within the past 12 months, or received exposure to
ionizing radiation
Locations and Contacts
Imperial College Hammersmith Campus, London W12 0HS, United Kingdom
Additional Information
Starting date: September 2005
Last updated: September 21, 2013
|