Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening
Information source: M.D. Anderson Cancer Center
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Adrenal Gland Diseases; Adrenal Gland Neoplasms
Intervention: I-131 Iodocholesterol (Drug)
Phase: Phase 3
Status: Completed
Sponsored by: M.D. Anderson Cancer Center Official(s) and/or principal investigator(s): Donald A. Podoloff, MD, Principal Investigator, Affiliation: M.D. Anderson Cancer Center
Summary
This is a clinical research study using I-131 Iodocholesterol which is an experimental
radioactive chemical that when injected into the vein, is picked up in the adrenal glands
and permits visualization with gamma imaging devices. These images are used in diagnosing a
variety of adrenal abnormalities. Prior to the injection of I-131 Iodocholesterol, the
patient will receive perchlorate capsules to block any uptake of I-131 by the thyroid gland
if this is deemed important. The patient will continue to take these capsules throughout the
period of imaging, which may last up to 1 week. The injection of I-131 Iodocholesterol will
be given into a vein and the patient will return for images on at least 1 and possibly 2
occasions between 3-7 days after injection. If the case requires it, the patient may also be
given a steroid in tablet form, dexamethasone, to take orally prior to and after the
injection to suppress normal adrenal function so that the abnormal tissues can be more
easily detected.
Clinical Details
Official title: Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening
Study design: Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Adults with suspected adrenal disease, such as adrenal adenoma, carcinoma, hyperplasia, or
Addison's Disease.
Locations and Contacts
University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, United States
Additional Information
Starting date: December 1988
Last updated: February 20, 2012
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