To determine which of 2 doses of dapsone is effective prophylaxis for Pneumocystis carinii
pneumonia (PCP) in patients with oral thrush or hairy leukoplakia and less than 400 CD4
lymphocytes per mm3. To determine whether the long-term toxicities associated with daily
dapsone in this population are tolerable.
Inclusion Criteria
The patient must have HIV positive antibody test and presence of oral thrush or hairy
leukoplakia.
- Patient must be willing and able to sign informed consent.
Exclusion Criteria
Co-existing Condition:
Patients with the following are excluded:
- Prior Pneumocystis carinii pneumonia (PCP) or AIDS-defining condition.
- Prophylaxis for PCP in preceding 3 months.
- Absence of detectable glucose-6-phosphate dehydrogenase (G6PD) activity.
- Prior type I hypersensitivity (anaphylaxis, urticaria, angioedema) or exfoliative
dermatitis during treatment with dapsone.
- History of poor compliance.
Concurrent Medication:
Excluded:
- Zidovudine (AZT).
Patients with the following are excluded:
- Prior Pneumocystis carinii pneumonia (PCP) or AIDS-defining condition.
- Prophylaxis for PCP in preceding 3 months.
- Absence of detectable glucose-6-phosphate dehydrogenase (G6PD) activity.
- Concurrent or prior therapy with zidovudine (AZT).
- Prior type I hypersensitivity (anaphylaxis, urticaria, angioedema) or exfoliative
dermatitis during treatment with dapsone.
- History of poor compliance.
Prior Medication:
Excluded:
- Zidovudine (AZT).
