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A Dose-response Study of Lidocaine and Etomidate

Information source: West China Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Etomidate Overdose of Undetermined Intent

Intervention: Lidocaine 1mg/kg (Drug); Lidocaine 1.5mg/kg (Drug); Lidocaine 2mg/kg (Drug); Lidocaine 2.5mg/kg (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: West China Hospital

Official(s) and/or principal investigator(s):
Liu Jin, MD, Study Director, Affiliation: West China Hospital


IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.

Clinical Details

Official title: Can Intravenous Lidocaine Decrease the Minimal Inducing Dose of Etomidate?: A Randomized Placebo-controlled Dose-response Study.

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Supportive Care

Primary outcome: changes in blood pressure and heart rate.

Detailed description: The study was carried out in West China Hospital of Sichuan University, Chengdu, China. All the patients were informed in detail about the procedure and the medications they are going to get. Patients are well informed about the beneficial and possible hazards of the medicines and procedure. Patients are also informed that they can withdraw from the study at any time if they find it uncomfortable or harmful for them. Patients' written informed consent was obtained and registered for the permission from the Hospital's Ethics Board.


Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Both.


Inclusion Criteria: 1. Patients scheduled for Elective Surgery, 2. age limit within 18-70 years, 3. American Society of Anaesthesiologists physical status classification I-II Exclusion Criteria: 1. Adrenal Cortex disorder, 2. Neurologic disease, 3. Psychiatric disorders, 4. Allergic to Local anesthetic drugs, 5. Patients who have received sedatives,analgesics or opioids within the previous 24 hrs.

Locations and Contacts

Additional Information

Starting date: April 2013
Last updated: August 1, 2013

Page last updated: August 23, 2015

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