A Dose-response Study of Lidocaine and Etomidate
Information source: West China Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Etomidate Overdose of Undetermined Intent
Intervention: Lidocaine 1mg/kg (Drug); Lidocaine 1.5mg/kg (Drug); Lidocaine 2mg/kg (Drug); Lidocaine 2.5mg/kg (Drug)
Phase: Phase 1
Status: Completed
Sponsored by: West China Hospital Official(s) and/or principal investigator(s): Liu Jin, MD, Study Director, Affiliation: West China Hospital
Summary
IV lidocaine administration can reduce the minimal amount of Etomidate and time for
induction of anesthesia.
Clinical Details
Official title: Can Intravenous Lidocaine Decrease the Minimal Inducing Dose of Etomidate?: A Randomized Placebo-controlled Dose-response Study.
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Supportive Care
Primary outcome: changes in blood pressure and heart rate.
Detailed description:
The study was carried out in West China Hospital of Sichuan University, Chengdu, China. All
the patients were informed in detail about the procedure and the medications they are going
to get. Patients are well informed about the beneficial and possible hazards of the
medicines and procedure. Patients are also informed that they can withdraw from the study at
any time if they find it uncomfortable or harmful for them. Patients' written informed
consent was obtained and registered for the permission from the Hospital's Ethics Board.
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
1. Patients scheduled for Elective Surgery,
2. age limit within 18-70 years,
3. American Society of Anaesthesiologists physical status classification I-II
Exclusion Criteria:
1. Adrenal Cortex disorder,
2. Neurologic disease,
3. Psychiatric disorders,
4. Allergic to Local anesthetic drugs,
5. Patients who have received sedatives,analgesics or opioids within the previous 24
hrs.
Locations and Contacts
Additional Information
Starting date: April 2013
Last updated: August 1, 2013
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