The Aim of This Investigation is to Compare the Influence of 0.9% Saline and Plasmalyte Solution on Acid-base Balance and Electrolytes in Healthy Patients Undergoing Major Spine Surgeries.
Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Spinal Surgery
Intervention: 0.9% normal saline (Other); plasmalyte (Other)
Phase: N/A
Status: Completed
Sponsored by: Yonsei University
Summary
Chloride-rich isotonic crystalloid solutions have been shown to exert electrolyte imbalance
and metabolic acidosis in critically ill patients. The aim of this investigation is to
compare the influence of 0. 9% saline and plasmalyte solution on acid-base balance and
electrolytes in healthy patients undergoing major spine surgeries.
Clinical Details
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
Primary outcome: base-excess
Eligibility
Minimum age: 20 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
1. 50 patients (aged 20-65) undergoing cervical or lumbar spine surgery who were diagnosed
spinal stenosis involving more than tow spinal levels.
Exclusion Criteria:
1. ASA class III or IV
2. pregnancy
3. breast feeding
4. lack of mental weakness(including disabled)
5. using diuretics
6. respiratory insufficiency
7. metabolic acidosis or alkalosis
8. coagulation disorder
9. over hydtration
10. renal failure or serum creatinine > 1. 4mg/dl
11. anemia (Hemoglobin 9. 0 145mEq/L)
13. Hyperkalemia (K>5. 5mEq/L)
14. psychological medication or any drugs that influences renal clearance
Locations and Contacts
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea, Republic of
Additional Information
Starting date: March 2012
Last updated: May 13, 2013
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