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The Aim of This Investigation is to Compare the Influence of 0.9% Saline and Plasmalyte Solution on Acid-base Balance and Electrolytes in Healthy Patients Undergoing Major Spine Surgeries.

Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Spinal Surgery

Intervention: 0.9% normal saline (Other); plasmalyte (Other)

Phase: N/A

Status: Completed

Sponsored by: Yonsei University

Summary

Chloride-rich isotonic crystalloid solutions have been shown to exert electrolyte imbalance and metabolic acidosis in critically ill patients. The aim of this investigation is to compare the influence of 0. 9% saline and plasmalyte solution on acid-base balance and electrolytes in healthy patients undergoing major spine surgeries.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: base-excess

Eligibility

Minimum age: 20 Years. Maximum age: 70 Years. Gender(s): Both.

Criteria:

Inclusion Criteria: 1. 50 patients (aged 20-65) undergoing cervical or lumbar spine surgery who were diagnosed spinal stenosis involving more than tow spinal levels. Exclusion Criteria: 1. ASA class III or IV 2. pregnancy 3. breast feeding 4. lack of mental weakness(including disabled) 5. using diuretics 6. respiratory insufficiency 7. metabolic acidosis or alkalosis 8. coagulation disorder 9. over hydtration 10. renal failure or serum creatinine > 1. 4mg/dl 11. anemia (Hemoglobin 9. 0 145mEq/L) 13. Hyperkalemia (K>5. 5mEq/L) 14. psychological medication or any drugs that influences renal clearance

Locations and Contacts

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea, Republic of
Additional Information

Starting date: March 2012
Last updated: May 13, 2013

Page last updated: August 23, 2015

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