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Pupillometry and Pain Thresholds Patients Substituted by Methadone and Buprenorphine

Information source: University Hospital, Clermont-Ferrand
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Opiate Dependent; Previous Illicit Drug Use

Intervention: Buprenorphine and Methadone Hydrochloride (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: University Hospital, Clermont-Ferrand

Official(s) and/or principal investigator(s):
Nicolas AUTHIER, Principal Investigator, Affiliation: University Hospital, Clermont-Ferrand

Overall contact:
Patrick LACARIN, Phone: 04 73 75 11 95, Email: placarin@chu-clermontferrand.fr

Summary

The purpose is to study the relation between pupillary diameter measured under scotopic conditions, and the pain thresholds measured at the time of peak and residual effect of methadone/buprenorphine in opiate-dependent patients following a substitution program.

Clinical Details

Official title: Pupillometry and Pain Thresholds Patients Substituted by Methadone and Buprenorphine.

Study design: Time Perspective: Cross-Sectional

Primary outcome: Measurement of the pupil diameter

Secondary outcome:

- The mechanical punctuate pain threshold as measured by Electronical Von Frey

- The mechanical pressure pain threshold measured by Algometer on the tibial bone

- The pupil diameter measured in scotopic .conditions (via infrared camera) at the hypothetical peak effect of either methadone or buprenorphine.

- The pupil diameter measured in photopic conditions (via infrared camera) at the hypothetical residual effect of either methadone or buprenorphine

Detailed description: Patients substituted since at least 3 months shall be included during a regular control visit. Each session shall consist in

- check for toxics in urine sample;

- measurement of pupil diameter;

- measurement of mechanical punctuate pain threshold;

- measurement of mechanical bone pain threshold.

A first session shall be done at time of residual effect of the opiate. A second session shall be done at time of peak effect of the opiate.

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- substitution treatment stable since at least 3 months

- capacity to understand the protocol

- likely to come to visits

- covered by French welfare

Exclusion Criteria:

- chronic pain

- concomitant acute pain

- pregnancy or breast feeding

- relevant mental disease

- peripheral neuropathy

- diabetes

- regular intake of ketamine

- neuroleptic concomitant treatment

Locations and Contacts

Patrick LACARIN, Phone: 04 73 75 11 95, Email: placarin@chu-clermontferrand.fr

CHU Clermont-Ferrand, Clermont-Ferrand 63003, France; Recruiting
Patrick LACARIN, Phone: 04 73 75 11 95, Email: placarin@chu-clermontferrand.fr
Additional Information

Starting date: February 2012
Last updated: January 11, 2013

Page last updated: August 23, 2015

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