For chronic HBV infection, an optimal pharmacological agent to promote recovery from chronic
HBV infection would be one that inhibits HBV DNA polymerase, combined with the clearence
from the liver of cccDNA to block HBV reactivation after the circulating viral burden has
been eliminated by therapy. The activity of clevudine on cccDNA in combination with its
potent antiviral activity on HBV polymerase makes it the optimal agent in combination with
tenofovir for this protocol.
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Inclusion Criteria:
- Male and female patients over 18 years of age
- Chronic hepatitis B, HBs Ag-positive for over 6 months, anti HBs negative
- Patients with HBeAg- negative chronic hepatitis B (CHB) and anti-HBe positive at
screen
- Patients naïve to anti-HBV nucleoside or nucleotide and any other experimental
nucleoside/nucleotide analog for HBV
- Serum HBV-DNA quantifiable over 2000 IU/mL at screening
- ALT over 1. 25 ULN and below 10 ULN
- Liver biopsy (baseline or within prior 6 months) with evidence of chronic hepatic
inflammatory injury (Metavir Activity score over 1 ; Knodell necroinflammatory score
over 3, Ishak score over 1)
Exclusion Criteria:
- Cirrhosis or bridging fibrosis on liver biopsy
- Subjects who have received any form of alpha interferon in the past 6 months prior to
the first administration of randomized treatment
- Any systemic anti-viral, anti-neoplastic or immuno-modulatory treatment (including
supraphysiologic doses of steroids and radiation) below 6 months prior to the first
dose of randomized treatment and during the study (except for below 10 days of
acyclovir for herpetic lesions, or prednisone below 10 mg/days for below 10 days more
than 1 month)
- Women with ongoing pregnancy or breast feeding
- Positive test at screening for anti-HAV IgM Ab, anti-HIV Ab, anti-HCV Ab, HCV RNA,
anti-HDV Ab
- History or other evidence of a medical condition associated with chronic liver
disease other than HBV (e. g., hemochromatosis, autoimmune hepatitis, metabolic liver
disease including Wilson's disease and alpha1-antitrypsin deficiency, alcoholic liver
disease, toxin exposures, toxic thalassemia, NASH)
- History or other evidence of bleeding from esophageal varices or other clinical
conditions consistent with decompensated liver disease (defined by one of the
following criteria being met: serum albumin below 3. 5 g/L, prothrombin time over 4
seconds prolonged, serum bilirubin over 34 µmol/L, history of encephalopathy, history
of ascites)
- Neutrophil count below 1200 cells/mm3 or platelet count below 90,000 cells/mm3 at
screening
- Serum creatinine level over 130µmol/l or calculated creatinine clearance below 70
ml/min (Cockcroft-Gault)
- Evidence or history of tubular nephropathy , Fanconi syndrom or hypophosphoremia.
- Evidence of drug abuse (including excessive alcohol consumption) within one year of
study entry
- History of a severe seizure disorder or current anticonvulsant use
- History of immunologically mediated disease (e. g., inflammatory bowel disease,
idiopathic thrombocytopenic purpura, lupus erythematosus, autoimmune hemolytic
anemia, scleroderma, severe psoriasis, rheumatoid arthritis etc.)
- History of major organ transplantation with an existing functional graft
- History or other evidence of severe illness or any other conditions which would make
the patient, in the opinion of the investigator, unsuitable for the study
- Evidence of an active or suspected cancer or a history of malignancy where the risk
of recurrence is over 20 % within 2 years
- Patients with a value of alpha-fetoprotein over 100 ng/mL are excluded, unless
stability (less than 10 % increase) has been documented over at least the previous 3
months
- Patients included in another trial within 8 weeks prior to screening
- Inability or unwillingness to provide informed consent or abide by the requirements
of the study Reassessments : If a patient fails to meet the above inclusion
/exclusion criteria for a reason thought to be reversible, that patient may be
reassessed for entry on two additional occasions at most. If the parameter out of
range for inclusion was ALT over 10 x ULN, the patient should be reassessed over 4
weeks after the date corresponding to the value that was over 10 x ULN.