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Comparison of Atrophogenic Effect of Hydrocortison 1% Cream and Pimecrolimus 1% Cream Assessed by Optical Coherence Tomography (OCT) and 20-MHz Ultrasound of Uninvolved Skin in Patients With Atopic Dermatitis

Information source: Technische Universitšt Dresden
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Atopic Dermatitis

Intervention: pimecrolimus 1% cream (Drug); hydrocortison 1% cream (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: Technische Universitšt Dresden

Official(s) and/or principal investigator(s):
Roland Aschoff, MD, Principal Investigator, Affiliation: Department of Dermatology, Medical Faculty, Technical University Dresden, Germany

Summary

to explore the atrophogenic potentials of hydrocortison 1% cream and pimecrolimus 1% cream on unaffected forehead skin

Clinical Details

Official title: Comparison of Atrophogenic Effect of Hydrocortison 1% Cream and Pimecrolimus 1% Cream Assessed by Optical Coherence Tomography (OCT) and 20-MHz Ultrasound of Uninvolved Skin in Patients With Atopic Dermatitis

Study design: Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Primary outcome: thickness of epidermis

Secondary outcome: thickness of dermis

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- age 18-60 years

- diagnosis of atopic dermatitis (Hanifin & Rajka Criteria)

- patients with atopic dermatitis not affecting the forehead

Exclusion Criteria:

- pregnancy / nursing mothers

- women in reproductive age without adequate contraception

- severe atopic dermatitis (IGA >= 4)

- UV-Therapy in past 4 weeks

- patients receiving any topical treatment on the face in past 6 month

Locations and Contacts

Department of Dermatology, Medical Faculty, TU Dresden, Dresden, Germany
Additional Information

Starting date: December 2007
Last updated: June 10, 2014

Page last updated: August 23, 2015

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