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Phenylephrine Versus Norepinephrine in Septic Shock

Information source: University of Roma La Sapienza
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Septic Shock

Intervention: Phenylephrine (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: University of Roma La Sapienza

Official(s) and/or principal investigator(s):
Andrea Morelli, MD, Principal Investigator, Affiliation: Departement of Anesthesiology and Intensive Care of the University of Rome "La Sapienza"

Summary

Clinical studies evaluating the clinical use of phenylephrine in septic shock are lacking. The present study was designed to compare the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic shock.

Clinical Details

Official title: Effects of Phenylephrine on Systemic and Regional Hemodynamics in Patients With Septic Shock: a Crossover Pilot Study

Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Systemic and regional hemodynamics

Secondary outcome: Organ functions, adverse effects

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Clical diagnosis of Septic Shock

- norepinephrine to maintain mean arterial pressure between 65 and 75 mmHg despite

adequate volume resuscitation (pulmonary artery occlusion pressure = 12-18 mmHg and central venous pressure = 8-12 mmHg). Exclusion Criteria:

- Age < 18 years

- Pregnancy

- Present or suspected acute coronary artery disease

- Present or suspected acute mesenteric ischemia.

Locations and Contacts

Department of Anesthesiology and Intensive care of the University of Rome "La Sapienza", Rome 00161, Italy
Additional Information

Starting date: January 2007
Last updated: May 30, 2007

Page last updated: August 23, 2015

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