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Nicotine Delivery Systems: Research & Treatment

Information source: Department of Veterans Affairs
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Smoking

Intervention: Nicotine gum - 2 mg and 4 mg (Drug); Nicotine lozenges - 2 mg and 4 mg (Drug); Nicotine inhaler (4 mg yield) - low and high "dosage" by frequency of puffing (Drug); Computer learning (Other)

Phase: N/A

Status: Terminated

Sponsored by: Department of Veterans Affairs

Official(s) and/or principal investigator(s):
Nina G. Schneider, PhD, Principal Investigator, Affiliation: VA Greater Los Angeles Healthcare System, West LA


The purpose of this study is to determine whether sampling nicotine replacement treatments (NRTs) is superior to learning about them by computer. Testing also covers preferences among the treatments. Subjects will be enrolled veterans who smoke. Hypothesis: Direct experience ("sampling") of NRTs will increase knowledge about NRTs, motivation/confidence, use of NRTs and quit attempts in contrast to learning about NRTs by computer.

Clinical Details

Official title: Nicotine Delivery Systems: Research and Treatment

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label

Primary outcome: Quit Attempts, Use of NRTs, Preference Among NRTs

Detailed description: The study was designed to compare sampling of several nicotine replacement treatments (NRTs) in contrast to a computer learning control. The NRTs include: 2 dosages of nicotine gum, 2 dosages of nicotine lozenges and 2 dosages of oral nicotine inhalers. In the sampling group, each participant tries each of the 6 NRTs for 3 minutes. In the control, the individuals read about the treatments. Dependent measures include: quit attempts, use of NRTs, preferences among NRTs, and learning and motivation.


Minimum age: 21 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- Must be enrolled veteran who smokes.

Exclusion Criteria:

- Any event or condition that could be exacerbated by the local effects of nicotine

treatments (e. g., throat or stomach problems; any kind of wheezing from a condition or medication)

- other criteria as determined by PI and study physicians

- reactions to menthol (inhaler) or to aspartame (lozenge)

Locations and Contacts

VA Greater Los Angeles Healthcare System, West LA, West Los Angeles, California 90073, United States
Additional Information

Starting date: October 2007
Last updated: June 2, 2014

Page last updated: August 23, 2015

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