Nicotine Delivery Systems: Research & Treatment
Information source: Department of Veterans Affairs
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Smoking
Intervention: Nicotine gum - 2 mg and 4 mg (Drug); Nicotine lozenges - 2 mg and 4 mg (Drug); Nicotine inhaler (4 mg yield) - low and high "dosage" by frequency of puffing (Drug); Computer learning (Other)
Sponsored by: Department of Veterans Affairs
Official(s) and/or principal investigator(s):
Nina G. Schneider, PhD, Principal Investigator, Affiliation: VA Greater Los Angeles Healthcare System, West LA
The purpose of this study is to determine whether sampling nicotine replacement treatments
(NRTs) is superior to learning about them by computer. Testing also covers preferences
among the treatments. Subjects will be enrolled veterans who smoke.
Hypothesis: Direct experience ("sampling") of NRTs will increase knowledge about NRTs,
motivation/confidence, use of NRTs and quit attempts in contrast to learning about NRTs by
Official title: Nicotine Delivery Systems: Research and Treatment
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label
Primary outcome: Quit Attempts, Use of NRTs, Preference Among NRTs
The study was designed to compare sampling of several nicotine replacement treatments (NRTs)
in contrast to a computer learning control. The NRTs include: 2 dosages of nicotine gum, 2
dosages of nicotine lozenges and 2 dosages of oral nicotine inhalers. In the sampling
group, each participant tries each of the 6 NRTs for 3 minutes. In the control, the
individuals read about the treatments. Dependent measures include: quit attempts, use of
NRTs, preferences among NRTs, and learning and motivation.
Minimum age: 21 Years.
Maximum age: 65 Years.
- Must be enrolled veteran who smokes.
- Any event or condition that could be exacerbated by the local effects of nicotine
treatments (e. g., throat or stomach problems; any kind of wheezing from a condition
- other criteria as determined by PI and study physicians
- reactions to menthol (inhaler) or to aspartame (lozenge)
Locations and Contacts
VA Greater Los Angeles Healthcare System, West LA, West Los Angeles, California 90073, United States
Starting date: October 2007
Last updated: June 2, 2014