Quetiapine vs Haloperidol Decanoate for the Long Term Treatment of Schizophrenia and Schizoaffective Disorder
Information source: Department of Veterans Affairs
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Schizophrenia; Schizoaffective Disorder
Intervention: quetiapine (Drug); haloperidol decanoate (Drug)
Phase: N/A
Status: Completed
Sponsored by: Department of Veterans Affairs
Summary
The purpose of this research study is to determine whether a new drug for schizophrenia is
better for the maintenance treatment than a standard drugs currently prescribed. The new
medication is called quetiapine and it will be compared with a standard medication called
haloperidol decanoate. The study will determine if quetiapine causes fewer problems than
haloperidol with side effects such as stiffness and restlessness and whether it costs the VA
more or less to treat patients with quetiapine. In addition, blood samples will be
collected every three months to determine if certain chemicals in the blood can influence
the outcome of the subjects' illness.
Clinical Details
Official title: Predicting the Optimal Pharmacotherapy for Outpatients With Schizophrenia
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Primary Purpose: Treatment
Eligibility
Minimum age: 18 Years.
Maximum age: 60 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria
1. Schizophrenia or Schizoaffective Disorder diagnosed by DSM-IV
2. Between the ages 18-60.
3. A candidate for maintenance antipsychotic therapy. This means that patients will
have had at least two documented episodes of acute schizophrenic illness or at least
two years of continuing psychotic symptoms.
Exclusion Criteria
1. Organic brain disease.
2. Mental Retardation
3. Chronic medical illness which would make antipsychotic medication inappropriate.
Locations and Contacts
VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, United States
Additional Information
Starting date: April 1997
Last updated: January 20, 2009
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