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Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma

Information source: National Cancer Institute (NCI)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Adult Solid Neoplasm; Recurrent Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma

Intervention: Laboratory Biomarker Analysis (Other); Pharmacological Study (Other); Riluzole (Drug); Sorafenib Tosylate (Drug)

Phase: Phase 1

Status: Recruiting

Sponsored by: National Cancer Institute (NCI)

Official(s) and/or principal investigator(s):
Janice Mehnert, Principal Investigator, Affiliation: Rutgers Cancer Institute of New Jersey

Summary

This phase I trial studies the side effects and best dose of sorafenib tosylate when given together with riluzole in treating patients with advanced solid tumors or melanoma. Riluzole may stop or slow the growth of tumor cells. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving riluzole together with sorafenib tosylate may kill more tumor cells.

Clinical Details

Official title: A Phase I Trial of Riluzole and Sorafenib in Patients With Advanced Solid Tumors and Melanoma

Study design: Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Maximum-tolerated dose of sorafenib tosylate and riluzole in patients with all types of solid tumors

Secondary outcome:

Change in BCL-2 expression

Change in BIM expression

Change in MCL-1 expression

Change in microvesicle quantification

Pharmacokinetic parameters of the combination of riluzole with sorafenib tosylate

Suppression of MAPK and PI3K/AKT pathways

Detailed description: PRIMARY OBJECTIVES: I. To define a safe dose of sorafenib (sorafenib tosylate) to combine with riluzole in the treatment of patients with all types of solid tumors refractory to standard therapy or for whom no standard therapy exists. SECONDARY OBJECTIVES: I. To examine the correlation of clinical or radiologic response with signaling through the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathways. II. To determine if response to therapy with riluzole and sorafenib correlates with expression levels of B-cell lymphoma (BCL)-2, myeloid cell leukemia (MCL)-1, or BCL2-like 11 (apoptosis facilitator) (BIM). III. To characterize the pharmacokinetics of the combination of riluzole with sorafenib and determine if any drug-drug interactions exist. IV. To evaluate the microvesicle (an inter-cellular communication approach which may cargo proteins, ribonucleic acids [RNAs] and deoxyribonucleic acids [DNAs] to its host cell) quantification difference between pre-treatment and post-treatment peripheral blood samples of patients. OUTLINE: This is a dose-escalation study of sorafenib tosylate. Patients receive riluzole orally (PO) twice daily (BID) and sorafenib tosylate PO once daily (QD) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study therapy, patients are followed up for approximately 2-3 years.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients must have histologically proven solid tumors (Phase I) or stage III

unresectable or stage IV metastatic melanoma with biopsiable tumor (expansion cohort) refractory to standard therapy or for whom no standard therapy exists or who decline standard therapy

- Eastern Cooperative Oncology Group (ECOG) performance status =< 2

- Patients must be willing and able to sign informed consent

- Unlimited prior therapies are permitted for patients enrolled in the dose escalation

phase of the study; patients in the expansion cohort of the study may not have any prior therapy with riluzole or sorafenib

- Patients may have measurable or evaluable disease

- Absolute neutrophil count (ANC) >= 1,500/uL

- Platelets >= 100,000/uL

- Total bilirubin =< 1. 5 x institutional upper limit of normal (ULN)

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and

alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2. 5 x institutional ULN

- International normalized ratio (INR) =< 1. 5 x institutional ULN

- Creatinine =< 2 x ULN

- Patients with brain lesions that have been treated with whole brain radiotherapy and

are clinically stable for at least 4 weeks, are not taking steroids and are not receiving enzyme-inducing anticonvulsants will be eligible Exclusion Criteria:

- Serious concomitant systemic disorders (including active infections) that would

compromise the safety of the patient or compromise the patient's ability to complete the study, at the discretion of the investigator

- For patients who have received gamma knife or stereotactic radiosurgery, a 2 week

washout is required; patients who have had other types of radiotherapy, chemotherapy or biologic agents within 3 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 3 weeks earlier to =< grade 1; at least 4 weeks must have elapsed since any major surgery; patients with prostate cancer may continue to receive hormonal therapy

- History of allergic reactions attributed to riluzole or sorafenib

- Women of child-bearing potential and men must agree to use adequate contraception

(hormonal, barrier method of birth control, abstinence) prior to study entry, for the duration of study participation, and for 2 weeks after discontinuation of riluzole and/or sorafenib; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately; pregnant (positive pregnancy test) or lactating patients cannot participate

- Known human immunodeficiency virus (HIV) infection, or known history of active

hepatitis B or C infection

- Current, recent (within 4 weeks of the first treatment of this study), or planned

participation in an experimental drug study (prevention trials are permitted if the trial is not testing a novel experimental agent)

- Cardiac disease: congestive heart failure > class II New York Heart Association

(NYHA); patients must not have unstable angina (anginal symptoms at rest) or new onset angina (began within the last 3 months) or myocardial infarction within the past 6 months

- History of stroke within six months

- Clinically significant peripheral vascular disease

- Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy

- Uncontrolled hypertension, defined as systolic blood pressure > 150 mm Hg or

diastolic blood pressure > 90 mm Hg, despite optimal medical management

- Active clinically serious infection > Common Terminology Criteria for Adverse Events

(CTCAE) grade 2

- Any of the following within 6 months prior to first dose of treatment: myocardial

infarction, symptomatic coronary artery disease (severe or unstable angina), artery bypass graft, uncontrolled arrhythmias, symptomatic congestive heart failure, cerebrovascular accident or transient ischemic attack, or pulmonary embolus

- Pulmonary hemorrhage/bleeding event >= CTCAE grade 2 within 4 weeks of first-dose of

study drug

- Any other hemorrhage/bleeding event >= CTCAE grade 3 within 4 weeks of first dose of

study drug

- Evidence or history of bleeding diathesis or coagulopathy

- Major surgery or significant traumatic injury within 4 weeks of first study drug

- The eligibility of patients taking medications that are potent modulators of

cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4), CYP2B6, 2C8 will be determined following a review of their case by the principal investigator; every effort should be made to switch patients taking such agents or substances to other medications

- Any condition that impairs the patient's ability to swallow whole pills

- Any malabsorption problem

- Anticipation of need for major surgical procedure during the course of the study

- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal

abscess within 6 months prior to day 1 of treatment

- Serious, non-healing wound, ulcer, or bone fracture

- Inability to comply with study and/or follow-up procedures

- Anticoagulation with Lovenox (enoxaparin) is permitted, however, patients on

anticoagulation with warfarin are not permitted on this study

Locations and Contacts

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, United States; Recruiting
Janice M. Mehnert, Phone: 732-235-6031, Email: mehnerja@cinj.rutgers.edu
Janice M. Mehnert, Principal Investigator
Additional Information

Starting date: February 2011
Last updated: July 2, 2015

Page last updated: August 23, 2015

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