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Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)

Information source: Columbia University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Post Operative Pain

Intervention: Morphine PCA (Drug); Hydromorphone PCA (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Columbia University

Official(s) and/or principal investigator(s):
Pamela Flood, MD, Principal Investigator, Affiliation: Columbia University


Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at our institution that hydromorphone causes less side effects but this has not been studied. We propose to treat our patients with either morphine or hydromorphone and determine how much nausea, vomiting, and itching they have with each drug

Clinical Details

Official title: The Comparison of Morphine and Hydromorphone Patient-Controlled Analgesia

Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Nausea Assessment by Patient

Secondary outcome:

Mean Score on the Numeric Rating Scare (NRS) Pruritus Scale

Pain Assessment by Patient

The Number of Patients Who Vomited

Mean Score on the Ramsey Scale of Sedation

Detailed description: Patients having general surgery at Columbia University Medical Center that will require Patient-Controlled Analgesia Inclusion: 18-60. American Society of Anesthesiologists (ASA) 1-2 Exclusion, pregnancy, lactation, chronic pain or opioids prior to surgery


Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.


Inclusion Criteria:

- patients scheduled for abdominal surgery requiring post-operative PCA

- ASA = I or II

Exclusion Criteria:

- preoperative pain or use of pain medication

- narcotic allergy

- morbid obesity (Body Mass Index > 30)

- diagnosis of sleep apnea

- hepatic or renal disease

- use of medications that would affect narcotic pharmacodynamics

- preoperative nausea, vomiting, or pruritis

- diagnosis of alcoholism

Locations and Contacts

Columbia Presbyterian Hospital, New York, New York 10032, United States
Additional Information

Starting date: November 2003
Last updated: March 3, 2015

Page last updated: August 23, 2015

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