Comparison of Side Effects of Morphine and Hydromorphone PCA
Information source: Columbia University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Post Operative Pain; Post Operative Side Effects of Narcotic Pain Medications
Intervention: Morphine PCA (Drug); Hydromorphone PCA (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Columbia University Official(s) and/or principal investigator(s):
Pamela Flood, MD, Principal Investigator, Affiliation: Columbia University Medical Center
Summary
Both morphine and hydromorphone are pain medications commonly used after surgery. It is
thought at our institution that hydromorphone causes less side effects but this has not been
studied. We propose to treat our patients with either morphine or hydromorphone and
determine how much nausea, vomiting, and itching they have with each drug
Clinical Details
Official title: Comparison of Morphine and Hydromorphone PCA
Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Active Control, Parallel Assignment, Pharmacodynamics Study
Primary outcome: Nausea
Secondary outcome: Pruritis, pain report NRS, vomiting, sedation
Eligibility
Minimum age: 18 Years.
Maximum age: 60 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- patients scheduled for abdominal surgery requiring post-operative PCA
- ASA = I or II
Exclusion Criteria:
- preoperative pain or use of pain medication
- narcotic allergy
- morbid obesity (BMI > 30)
- diagnosis of sleep apnea
- hepatic or renal disease
- use of medications that would affect narcotic pharmacodynamics
- preoperative nausea, vomiting, or pruritis
- diagnosis of alcoholism
Locations and Contacts
Columbia Presbyterian Hospital, New York, New York 10032, United States
Additional Information
Starting date: November 2003
Ending date: October 2007
Last updated: October 29, 2007
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