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Comparison of Side Effects of Morphine and Hydromorphone PCA

Information source: Columbia University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Post Operative Pain; Post Operative Side Effects of Narcotic Pain Medications

Intervention: Morphine PCA (Drug); Hydromorphone PCA (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Columbia University

Official(s) and/or principal investigator(s):
Pamela Flood, MD, Principal Investigator, Affiliation: Columbia University Medical Center

Summary

Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at our institution that hydromorphone causes less side effects but this has not been studied. We propose to treat our patients with either morphine or hydromorphone and determine how much nausea, vomiting, and itching they have with each drug

Clinical Details

Official title: Comparison of Morphine and Hydromorphone PCA

Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Active Control, Parallel Assignment, Pharmacodynamics Study

Primary outcome: Nausea

Secondary outcome: Pruritis, pain report NRS, vomiting, sedation

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- patients scheduled for abdominal surgery requiring post-operative PCA

- ASA = I or II

Exclusion Criteria:

- preoperative pain or use of pain medication

- narcotic allergy

- morbid obesity (BMI > 30)

- diagnosis of sleep apnea

- hepatic or renal disease

- use of medications that would affect narcotic pharmacodynamics

- preoperative nausea, vomiting, or pruritis

- diagnosis of alcoholism

Locations and Contacts

Columbia Presbyterian Hospital, New York, New York 10032, United States
Additional Information

Starting date: November 2003
Ending date: October 2007
Last updated: October 29, 2007

Page last updated: June 20, 2008

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