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Drug Therapy for Alcohol Detoxification

Information source: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Alcoholism

Intervention: lorazepam (Ativan) (Drug); carbamazepine (Tegretol) (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Summary

This project will provide relevant clinical information for primary care practitioners treating alcohol withdrawal syndrome in outpatient settings. This double-blind, placebo- controlled clinical trial will compare the effectiveness of lorazepam (Ativan) and carbamazepine (Tegretol) in alcoholics who meet the criteria for a diagnosis of uncomplicated alcohol withdrawal syndrome. Participants are randomized to five days of treatment with a 1-week posttreatment followup.

Clinical Details

Official title: Carbamazepine and Lorazepam in Outpatient Detoxification

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Masking: Double-Blind, Primary Purpose: Treatment

Eligibility

Minimum age: 21 Years. Maximum age: 70 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Meets criteria for alcohol dependence and uncomplicated alcohol withdrawal syndrome.

- Ability to provide informed consent, complete self-rating questionnaires, and respond

to structured clinician-rated instruments.

- Must live within 50 miles or one hour of the study site and have reliable

transportation to the site.

- Must have a significant other who will provide a collateral report, attend outpatient

visits, and be available by telephone.

- Subjects must be medically stable.

- Must have a clinical withdrawal assessment prior to study.

Exclusion Criteria:

- Meets criteria for any other substance dependence syndrome other than alcohol

dependence or marijuana abuse.

- Use of other illicit psychoactive substances (except marijuana) in the last 7 days.

- Use of pharmaceutical agents within the last 14 days that are known to lower the

seizure threshold, augment or decrease the alcohol withdrawal syndrome.

- History of status epilepticus or two or more seizures occurring within 24- hour

period during a previous alcohol withdrawal or other forms of epilepsy.

- Current major depressive illness, dementia, suicidal or homicidal ideation, or past

or present schizophrenia.

- Acute medical instability as characterized by hepatic encephalopathy, past or present

severe liver failure.

- Diabetes requiring insulin, or severe renal disease.

- Pregnant females.

- High blood pressure.

- Individuals with vomiting who cannot take oral medications at beginning of study or

whose vomiting can be controlled only with antiemetic medication.

- High white blood count, or liver function test that is 3 times higher than normal.

- Known hypersensitivity or previous adverse reaction to carbamazepine, lorazepam, or

other benzodiazepines.

- Any relevant ECG abnormality which might require hospitalization or greatly interfere

with safety during outpatient withdrawal.

- History of severe gastrointestinal (GI) disease which might render absorption of the

medication difficult or produce medical instability of the patient during detoxification which would include active peptic ulcer disease, ulcerative colitis, regional ileitis, or evidence by history or physical examination of GI bleeding.

- Familial tremor or other neurological condition, determined by history, known to

produce tremor.

- Unable to provide a written informed consent.

Locations and Contacts

Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, United States
Additional Information


Last updated: June 23, 2005

Page last updated: August 23, 2015

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