Research of the Application of Triple Antibiotic Paste in Primary Teeth With Pericpical Periodontitis
Information source: Sun Yat-sen University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Periapical Diseases
Intervention: Metronidazole-Ciprofloxacin gatifloxacin-Clindamycin paste (Drug); creosote (Drug)
Phase: N/A
Status: Active, not recruiting
Sponsored by: Lin Jiacheng Official(s) and/or principal investigator(s):
Jiacheng Lin, Study Chair, Affiliation: Guanghua hospital of stomotology,Sun Yat-sen University
Summary
The triple antibiotic paste is widely used in young permanent teeth and permanent teeth
root canal therapy with excellent antiantimicrobial effect. We hypothesize that its
application in the treatment of periapical periodontitis of deciduous teeth is superior to
other drugs currently in use as creosote.
Clinical Details
Official title: Randomized Controlled Research of the Application of Triple Antibiotic Paste in Primary Teeth With
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Primary outcome: Evidence of lesion healing confirmed by cone beam computed tomography and X-rays
Detailed description:
We design to collect a group of patients presenting primary teeth with periapical
periodontitis in certain criterion. We will divide the patients into two groups randomly. One
group will get treated with triple antibiotic paste while the other with creosote. We want
to evaluate the short-term and long-term effects of the two groups to get a conclusion of
the clinical value of triple antibiotic paste.
Eligibility
Minimum age: 3 Years.
Maximum age: 8 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- clinical diagnosis of periapical periodontitis
- must be primary teeth
- must be 3~8 years old
- the permanent tooth germ is complete and didnot be involved
Exclusion Criteria:
- blood disease
- residual root that is advised to extract
- serious periodontitis
- allergy to the triple antibiotic paste
Locations and Contacts
Jicheng Lin, Guangzhou, Guangdong 510055, China
Additional Information
Related publications: Bezgin T, Yilmaz AD, Celik BN, Sönmez H. Concentrated platelet-rich plasma used in root canal revascularization: 2 case reports. Int Endod J. 2014 Jan;47(1):41-9. doi: 10.1111/iej.12144. Epub 2013 Jun 17. Nagata JY, Gomes BP, Rocha Lima TF, Murakami LS, de Faria DE, Campos GR, de Souza-Filho FJ, Soares Ade J. Traumatized immature teeth treated with 2 protocols of pulp revascularization. J Endod. 2014 May;40(5):606-12. doi: 10.1016/j.joen.2014.01.032. Epub 2014 Mar 6. Nagata JY, Soares AJ, Souza-Filho FJ, Zaia AA, Ferraz CC, Almeida JF, Gomes BP. Microbial evaluation of traumatized teeth treated with triple antibiotic paste or calcium hydroxide with 2% chlorhexidine gel in pulp revascularization. J Endod. 2014 Jun;40(6):778-83. doi: 10.1016/j.joen.2014.01.038. Epub 2014 Apr 29.
Starting date: June 2013
Last updated: July 21, 2014
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