Comparison of Pantoprazole and Ranitidine in Dyspepsia
Information source: Akdeniz University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Dyspepsia
Intervention: Pantoprazole (Drug); Ranitidine (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Akdeniz University Official(s) and/or principal investigator(s): Cenker Eken, Proffesor, Study Director, Affiliation: Akdeniz University
Summary
The H0 hypothesis of the study is there is no difference between pantoprazole and ranitidine
in treating patients presented with dyspepsia to the emergency department.
The H1 hypothesis is there is difference between pantoprazole and ranitidine in treating
patients presented with dyspepsia to the emergency department.
Clinical Details
Official title: Intravenous Pantoprazole vs Ranitidine in Dyspepsia in Emergency Department: A Randomized Controlled Trial.
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Visual Analogue Scale Score
Secondary outcome: Need for Additional Drug
Detailed description:
Dyspepsia is one of the common complaints in emergency department. Proton pomp inhibitors,
H2 receptor blockers and anti-acids are common drugs for treating dyspepsia in emergency
department. However there is no study in the emergency department comparing the
effectiveness of these drugs. So the investigators planned this study which drug is
effective in these patients in order to provide a cost-effective treatment in dyspeptic
patients.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Epigastric pain
- Older than 18 years old
Exclusion Criteria:
- Diagnosed as cholecystitis, pancreatitis, myocardial infarction, etc.. at the end of
the emergency deparment evaluation period.
- Pregnancy
- Patients with unstable vital signs
- Patients used anti-acid, H2 receptor blockers and proton pomp inhibitors in the last
one hour.
- Allergy to H2 receptor blockers and proton pomp inhibitors.
- Patients denied to give inform consent and who are illiterate
Locations and Contacts
Akdeniz University, Antalya 07050, Turkey
Additional Information
The web adress of the organization which this study is conducted.
Related publications: Welling LR, Watson WA. The emergency department treatment of dyspepsia with antacids and oral lidocaine. Ann Emerg Med. 1990 Jul;19(7):785-8.
Starting date: October 2012
Last updated: June 27, 2015
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