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Clofarabine, Cytarabine, and Idarubicin in Treating Patients With Intermediate-Risk or High-Risk Acute Myeloid Leukemia or High-Risk Myelodysplasia

Information source: European Organisation for Research and Treatment of Cancer - EORTC
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Leukemia; Myelodysplastic Syndromes

Intervention: clofarabine (Drug); cytarabine (Drug); idarubicin (Drug)

Phase: Phase 1/Phase 2

Status: Recruiting

Sponsored by: European Organisation for Research and Treatment of Cancer - EORTC

Official(s) and/or principal investigator(s):
Roel Willemze, Principal Investigator, Affiliation: EORTC (Phase I) - Leiden University Medical Center, NL
Dominik Selleslag, Principal Investigator, Affiliation: EORTC (Phase II) - AZ Sint-Jan, BE
Giovanna Meloni, Principal Investigator, Affiliation: GIMEMA (Phase I & II) - Universita Degli Studi "La Sapienza", IT

Overall contact:
Hilde Breyssens, Email: hilde.breyssens@eortc.be

Summary

RATIONALE: Drugs used in chemotherapy, such as clofarabine, cytarabine, and idarubicin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. PURPOSE: This randomized phase I/II trial is studying the side effects and best dose of clofarabine and to see how well it works when given together with cytarabine and idarubicin in treating patients with intermediate-risk or high-risk acute myeloid leukemia or high-risk myelodysplasia.

Clinical Details

Official title: Clofarabine in Combination With a Standard Remission Induction Regimen (AraC and Idarubicin) in Patients 18-60 Years Old With Previously Untreated Intermediate and Bad Risk Acute Myelogenous Leukemia (AML) or High Risk Myelodysplasia (MDS) : a Phase I-II Study of the EORTC-LG and GIMEMA (AML-14A Trial)

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome:

Toxicity as assessed by CTCAE v3.0 (Phase I)

Response rate (Phase II)

Secondary outcome:

Toxicity as assessed by CTCAE v3.0 (Phase II)

Response rate (Phase I)

Duration of survival

Duration of survival from complete remission (CR)/CR with incomplete hematopoietic recovery (CRi) rate

Disease-free survival from CR/CRi

Incidence of relapse and incidence of death in CR/CRi

Detailed description: OBJECTIVES: Primary

- To determine the optimum dose of clofarabine in combination with cytarabine and

idarubicin in patients with previously untreated intermediate- and high-risk acute myeloid leukemia or high-risk myelodysplasia. (Phase I)

- To determine the safety and tolerance of this regimen in order to determine the

recommended phase II dose. (Phase I)

- To explore the antitumor activity of this regimen in these patients. (Phase II)

- To determine the activity expressed as complete remission (CR)/CR with incomplete

hematopoietic recovery (CRi) rate following induction therapy. (Phase II) Secondary

- To determine the activity expressed as CR/CRi rate following induction (1 or 2 courses)

and consolidation therapy. (Phase I)

- To determine hematopoietic recovery (platelets and neutrophils) after induction and

consolidation therapy.

- To determine safety and tolerability of this regimen. (Phase II)

- To determine activity expressed as CR/CRi rate after consolidation therapy. (Phase II)

- To determine feasibility of blood CD34 harvesting after consolidation therapy. (Phase

II)

- To determine disease-free and overall survival from CR/CRi. (Phase II)

OUTLINE: This is a multicenter, phase I, dose-escalation study of clofarabine followed by an randomized phase II study. Patients are stratified according to center, and presence of poor prognostic features (WBC at diagnosis ≥ 100,000/μL vs presence of very high risk cytogenetic

features - 5/5q-, -7/7q-, presence of complex abnormalities [> 3 abnormalities], 3q, t[6;9],

or t[9;22]). Patients are randomized to 1 of 2 treatment arms.

- Induction therapy:

- Arm I: Patients receive idarubicin IV over 5 minutes on days 1, 3, and 5,

cytarabine IV continuously on days 1-10, and clofarabine IV over 1 hour on days 2, 4, 6, 8, and 10.

- Arm II: Patients receive idarubicin IV and cytarabine IV as in arm I. Patients

also receive clofarabine IV by push injection over 10 minutes on days 2, 4, 6, 8, and 10.

- Consolidation therapy: Patients receive cytarabine IV over 2 hours every 12 hours on

days 1-6 and idarubicin IV over 5 minutes once daily on days 4-6. After completion of study therapy, patients are followed periodically for 12 months.

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

DISEASE CHARACTERISTICS:

- Diagnosis of 1 of the following by WHO criteria:

- Acute myeloid leukemia (AML) (≥ 20% bone marrow blasts by bone marrow aspiration

or biopsy)

- No acute promyelocytic leukemia (M3)

- All cytogenetic groups allowed, except for the following:

- t(15;17)

- t(8;21) or inv(16) AND a WBC count at diagnosis of < 100,000/μL

- Primary or secondary AML allowed, including AML after myelodysplasia (MDS)

- High-risk MDS (≥ 10% bone marrow blasts by bone marrow aspiration or biopsy)

- No chronic myelogenous leukemia in blast crisis or AML supervening a

myeloproliferative disorder

- Previously untreated disease, except for ≤ 14 days of hydroxyurea

- No CNS leukemia

PATIENT CHARACTERISTICS:

- WHO performance status 0-2

- Serum creatinine ≤ 1. 0 mg/dL or glomerular filtration rate > 60 mL/min

- AST/ALT ≤ 2. 5 times upper limit of normal (ULN)

- ALP ≤ 2. 5 times ULN

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective barrier contraception during and for ≥ 3 months

after completion of study treatment

- No active uncontrolled infection

- No HIV positivity

- No psychological, familial, sociological, or geographical conditions precluding

compliance with study treatment or follow up

- No concurrent severe uncontrolled cardiovascular disease (i. e., symptomatic

congestive heart failure or symptomatic ischemic heart disease [NYHA class III-IV])

- No concurrent malignant disease

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- No concurrent cytotoxic drugs or experimental therapies (e. g., antiangiogenic drugs,

tyrosine kinase inhibitors)

Locations and Contacts

Hilde Breyssens, Email: hilde.breyssens@eortc.be

A.Z. Sint-Jan, Brugge, Belgium; Recruiting
Dominik Selleslag, Principal Investigator

Institut Jules Bordet, Brussel, Belgium; Not yet recruiting
Dominique Bron, Principal Investigator

CHU Sart-Tilman, Liège, Belgium; Not yet recruiting
Frédéric Baron, Principal Investigator

University Hospital Rebro, Zagreb, Croatia; Not yet recruiting
Boris Labar, Principal Investigator

Hôpital Saint Antoine AP-HP, Paris, France; Not yet recruiting
Olivier Legrand, Principal Investigator

Azienda Ospedallera Universitaria - Policlinico Tor Vergata, Roma, Italy; Recruiting
Sergio Amadori, Principal Investigator

Univesita Degli Studi "La Sapienza", Roma, Italy; Recruiting
Giovanna Meloni, Principal Investigator

Leiden University Medical Center, Leiden, Netherlands; Active, not recruiting

Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; Recruiting
Petra Muus, Principal Investigator

Jeroen Bosch Ziekenhuis, s' Hertogenbosch, Netherlands; Recruiting
Hans Pruijt, Principal Investigator

Additional Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Starting date: November 2008
Last updated: July 19, 2012

Page last updated: August 23, 2015

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