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Pilot Study to Assess the Efficacy of Short Exposure to Defocus to Slow the Progression of Myopia in Children

Information source: Singapore National Eye Centre
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Myopia

Intervention: Hyperopic lens (Device)

Phase: N/A

Status: Completed

Sponsored by: Singapore National Eye Centre

Official(s) and/or principal investigator(s):
Audrey Chia, FRANZCO, Principal Investigator, Affiliation: Singapore National Eye Center


The objective of this pilot study is to establish whether brief periods of high levels of acutely imposed myopic defocus can be used to slow the progression of myopia in children, as measured by changes in spherical equivalent refraction and axial length.

Clinical Details

Official title: Pilot Study to Assess the Efficacy of Short Exposure to Defocus to Slow the Progression of Myopia in Children

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Primary outcome: Myopia progression as measured by spherical equivalent, and axial length

Detailed description: Recent results on animal models of myopia suggest that the eye has the ability to detect the overall sign of defocus of images falling on the retina, with myopic defocus imposed by the fitting of plus-lenses halting or slowing axial elongation of the eye. In the animal models,

these STOP growth signals have been shown to be particularly strong - with brief periods of

high myopic defocus able to outweigh the effects of prolonged periods of imposed hyperopic defocus in promoting eye growth. These results therefore suggest a novel strategy for

preventing the progression of myopia in children - the imposition of high levels of myopia

for brief periods of time. This approach is conceptually distinct from under-correction, which imposes chronic mild myopic defocus.


Minimum age: 6 Years. Maximum age: 12 Years. Gender(s): Both.


Inclusion Criteria: 1. Children aged 6 to 12 years

2. Refractive error of spherical equivalent - 1. 00 D to -6. 00D in each eye as measured by

cycloplegic autorefraction

3. Active myopia progression of at least spherical equivalent - 0. 50 D over the last 12

months as determined or suggested by refractive records or change in lens power

4. Astigmatism of less than or equal to - 1. 50 D as measured by non-cycloplegic or

cycloplegic autorefraction 5. Distance vision correctable to logMAR 0. 1 or better in both eyes 6. Normal intraocular pressure of not greater than 21 mmHg 7. Normal ocular health other than myopia 8. In good general health 9. Willing and able to comply with scheduled visits and other study procedures Exclusion Criteria: 1. Baseline Anisometropia of > 1. 5D 2. Ocular or systemic diseases which may affect vision or refractive error 3. Defective binocular function or stereopsis 4. Amblyopia or manifest strabismus including intermittent tropia 5. Previous or current use of atropine or pirenzepine 6. Any other conditions precluding adherence to the protocol including unwillingness to refrain from contact lens wear for the duration of the study 7. Allergy to cyclopentolate, proparacaine and benzalkonium chloride

Locations and Contacts

SNEC, Singapore 168751, Singapore
Additional Information

Starting date: November 2006
Last updated: May 11, 2010

Page last updated: August 23, 2015

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