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Cardiac Allograft Vasculopathy and Dobutamine Stress Echocardiography / Brain Natriuretic Peptide Coupling

Information source: University Hospital, Strasbourg, France
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Vasculopathy; Allograft

Intervention: Dobutamine stress echocardiography, coronarography, brachial arterial echography (Procedure)

Phase: N/A

Status: Active, not recruiting

Sponsored by: University Hospital, Strasbourg, France

Official(s) and/or principal investigator(s):
Samy TALHA, MD, Principal Investigator, Affiliation: Hôpitaux Universitaires de Strasbourg

Summary

Primary purpose :To early detect cardiac allograft vasculopathy and to identify patients with high risk of cardiac events, by coupling the analysis of the kinetics of the brain natriuretic peptide ( BNP) with that of the left ventricle (LV) during a dobutamine stress echocardiography. Hypothesis : Plasma BNP elevation and abnormalities of LV kinetic during the ESD, will be associated with the presence of allograft vasculopathy and the arisen of cardiovascular events.

Clinical Details

Official title: Allograft Vasculopathy After Heart Transplantation : Diagnostic Interest of Dobutamine Stress Echocardiography and Brain Natriuretic Peptide Coupling

Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic

Primary outcome: Cardiovascular events vs Dobutamine stress echocardiography each 2 years

Secondary outcome: Flow mediated humeral dilatation each 2 years

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion criteria:

- Heart transplant recipients

Exclusion criteria:

- No respect of inclusion criteria

- Pregnancy

- Severe renal failure (creatinin clearance < or equal to 30 ml/min)

- Dobutamine stress echocardiography contraindication

Locations and Contacts

Service de Physiologie et d'Explorations Fonctionnelles, Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg 67091, France
Additional Information

Starting date: September 2006
Last updated: April 20, 2015

Page last updated: August 23, 2015

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