Cardiac Allograft Vasculopathy and Dobutamine Stress Echocardiography / Brain Natriuretic Peptide Coupling
Information source: University Hospital, Strasbourg, France
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Vasculopathy; Allograft
Intervention: Dobutamine stress echocardiography, coronarography, brachial arterial echography (Procedure)
Phase: N/A
Status: Active, not recruiting
Sponsored by: University Hospital, Strasbourg, France Official(s) and/or principal investigator(s): Samy TALHA, MD, Principal Investigator, Affiliation: Hôpitaux Universitaires de Strasbourg
Summary
Primary purpose :To early detect cardiac allograft vasculopathy and to identify patients
with high risk of cardiac events, by coupling the analysis of the kinetics of the brain
natriuretic peptide ( BNP) with that of the left ventricle (LV) during a dobutamine stress
echocardiography.
Hypothesis : Plasma BNP elevation and abnormalities of LV kinetic during the ESD, will be
associated with the presence of allograft vasculopathy and the arisen of cardiovascular
events.
Clinical Details
Official title: Allograft Vasculopathy After Heart Transplantation : Diagnostic Interest of Dobutamine Stress Echocardiography and Brain Natriuretic Peptide Coupling
Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic
Primary outcome: Cardiovascular events vs Dobutamine stress echocardiography each 2 years
Secondary outcome: Flow mediated humeral dilatation each 2 years
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion criteria:
- Heart transplant recipients
Exclusion criteria:
- No respect of inclusion criteria
- Pregnancy
- Severe renal failure (creatinin clearance < or equal to 30 ml/min)
- Dobutamine stress echocardiography contraindication
Locations and Contacts
Service de Physiologie et d'Explorations Fonctionnelles, Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg 67091, France
Additional Information
Starting date: September 2006
Last updated: April 20, 2015
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