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Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

Information source: Zhujiang Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hemodynamics; Oxidative Stress; Anesthesia

Intervention: midazolam (Drug); Penehyclidine Hydrochloride Injection (Drug); Etomidate (Drug); Propofol (Drug); Fentanyl (Drug); Cisatracurium Besilate (Drug); Remifentanil (Drug); Sevoflurane (Drug)

Phase: Phase 4

Status: Not yet recruiting

Sponsored by: Zhujiang Hospital

Summary

To explore the effect of induction and maintenance of anesthesia with etomidate on hemodynamics and oxidative stress in diabetic patients.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome:

Mean arterial pressure

Central venous pressure

Heart rate

Respiratory rate

Oxygen saturation

Blood glucose

Insulin

Secondary outcome:

Super oxide dismutase

Glutathione

Xanthine oxidase

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Aged between 18 and 65 years;

- Diabetic patients preparing for elective surgery;

- Body mass index is between 16 and 30 kg/m2;

- Blood glucose is under 8. 3 mmol/kg by oral antidiabetic agents or diet control;

- American Society of Anesthesiology (ASA) Physical Status: Ⅰ or Ⅱ;

- Expected operation duration is between 2 and 8 h;

- Signed informed consent form.

Exclusion Criteria:

- Severe cardiac, cerebral, liver, kidney, lung, endocrine disease or infectious

disease;

- Chemotherapy or immunotherapy before the surgery;

- Allergy to trial drug or other contraindication;

- Expected or history of difficult airway;

- Suspected abuse of narcotic analgesia;

- Diseases of neuromuscular system;

- Mentally unstable or has a mental illness;

- Trend of malignant hyperthermia;

- Pregnant or breast-feeding women;

- Attendance of other trial past 30 days.

Locations and Contacts

Additional Information

Starting date: September 2014
Last updated: July 24, 2014

Page last updated: August 23, 2015

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