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Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics

Information source: Seoul St. Mary's Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Laparoscopic Renal Surgery; Laparoscopy; Muscle Relaxation

Intervention: Rocuronium (Drug); Rocuronium (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Seoul St. Mary's Hospital

Official(s) and/or principal investigator(s):
Sang-Hyun Hong, MD, Principal Investigator, Affiliation: Seoul St. Mary's Hospital

Overall contact:
Sang-Hyun Hong, MD, Phone: 82-2-2258-2236, Email: shhong7272@gmail.com


The primary objective of the current study is to compare intraoperative respiratory mechanics in patients receiving laparoscopic renal surgery under deep neuromuscular blockade (dNMB) and under moderate neuromuscular blockade (mNMB). In addition, we will compare intraoperative hemodynamics and postoperative pulmonary function between the two groups.

Clinical Details

Official title: Effects of Deep Versus Moderate Neuromuscular Blockade on Intraoperative Respiratory Mechanics in Patients Undergoing Laparoscopic Renal Surgery: a Prospective, Randomized, Parallel Design Study

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Supportive Care

Primary outcome: Thoracopulmonary compliance

Secondary outcome:

Arterial oxygen tension/inspired oxygen fraction

Arterial to end-tidal partial pressure of carbon dioxide difference

Physiologic dead space

Pulmonary shunt


Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Both.


Inclusion Criteria:

- ASA I or II patients scheduled to undergo laparoscopic renal surgery

Exclusion Criteria:

- BMI ≥35 kg/m2

- Known neuromuscular disease

- History of chronic obstructive pulmonary disease

- Asthma

- Pneumothorax

- Bronchopleural fistula

- Previous lung surgery

- Hemodynamic instability

- History of cardiopulmonary disease

- Renal insufficiency

Locations and Contacts

Sang-Hyun Hong, MD, Phone: 82-2-2258-2236, Email: shhong7272@gmail.com

Seoul St. Mary's Hospital, Seoul 137-701, Korea, Republic of; Recruiting
Additional Information

Starting date: July 2014
Last updated: July 14, 2014

Page last updated: August 23, 2015

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