Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics
Information source: Seoul St. Mary's Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Laparoscopic Renal Surgery; Laparoscopy; Muscle Relaxation
Intervention: Rocuronium (Drug); Rocuronium (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Seoul St. Mary's Hospital Official(s) and/or principal investigator(s):
Sang-Hyun Hong, MD, Principal Investigator, Affiliation: Seoul St. Mary's Hospital
Overall contact:
Sang-Hyun Hong, MD, Phone: 82-2-2258-2236, Email: shhong7272@gmail.com
Summary
The primary objective of the current study is to compare intraoperative respiratory
mechanics in patients receiving laparoscopic renal surgery under deep neuromuscular blockade
(dNMB) and under moderate neuromuscular blockade (mNMB). In addition, we will compare
intraoperative hemodynamics and postoperative pulmonary function between the two groups.
Clinical Details
Official title: Effects of Deep Versus Moderate Neuromuscular Blockade on Intraoperative Respiratory Mechanics in Patients Undergoing Laparoscopic Renal Surgery: a Prospective, Randomized, Parallel Design Study
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Supportive Care
Primary outcome: Thoracopulmonary compliance
Secondary outcome: Arterial oxygen tension/inspired oxygen fractionArterial to end-tidal partial pressure of carbon dioxide difference Physiologic dead space Pulmonary shunt
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- ASA I or II patients scheduled to undergo laparoscopic renal surgery
Exclusion Criteria:
- BMI ≥35 kg/m2
- Known neuromuscular disease
- History of chronic obstructive pulmonary disease
- Asthma
- Pneumothorax
- Bronchopleural fistula
- Previous lung surgery
- Hemodynamic instability
- History of cardiopulmonary disease
- Renal insufficiency
Locations and Contacts
Sang-Hyun Hong, MD, Phone: 82-2-2258-2236, Email: shhong7272@gmail.com
Seoul St. Mary's Hospital, Seoul 137-701, Korea, Republic of; Recruiting
Additional Information
Starting date: July 2014
Last updated: July 14, 2014
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