The purpose of this study is to evaluate the effects of Ceftazidime Avibactam plus
Metronidazole compared to Meropenem for treating hospitalized patients with complicated
intra-abdominal infections.
The proportion of patients with clinical cure in the microbiologically evaluable and extended microbiologically evaluable analysis setThe proportion of patients with clinical cure in the microbiological modified intent-to-treat, microbiologically evaluable, and extended microbiologically evaluable analysis sets
The proportion of patients with clinical cure in the clinically evaluable analysis set
The proportion of patients with a favorable per-patient microbiological response in the microbiological modified intent to treat, microbiologically evaluable, and extended microbiologically evaluable analysis sets
The proportion of favorable per-pathogen microbiological response in the microbiological modified intent to treat, microbiologically evaluable, and extended microbiologically evaluable analysis sets
The favorable per-pathogen microbiologic response by minimum inhibitory concentration (MIC)categories in the microbiological modified intent to treat, microbiologically evaluable,and extended microbiologically evaluable analysis sets
Favorable per-patient clinical response & microbiological response for patients infected with ceftazidime-resistant pathogens in microbiological modified intent to treat, microbiologically evaluable & extended microbiologically evaluable analysis sets
Proportion of patients with favorable per-pathogen microbiological response for patients infected with ceftazidime-resistant pathogens in microbiological modified ITT, microbiologically evaluable and extended microbiologically evaluable analysis sets
The time to first defervescence in the clinically evaluable, microbiologically evaluable, and extended microbiologically evaluable analysis sets for patients who have fever at study entry
The safety and tolerability by incidence and severity of adverse events and serious adverse events, vital signs, clinical laboratory tests, ECGs and physical exams.
Pharmacokinetics: maximum concentration (Cmax), minimum concentration, area under the plasma concentration time curve at steady state, and terminal half-life
Minimum age: 18 Years.
Maximum age: 90 Years.
Gender(s): Both.
Research Site, Mendoza, Argentina
Research Site, Santa Fe, Argentina
Research Site, Antwerpen, Belgium
Research Site, Brussels (Jette), Belgium
Research Site, Belo Horizonte, Brazil
Research Site, Curitiba, Brazil
Research Site, Passo Fundo, Brazil
Research Site, Plovdiv, Bulgaria
Research Site, Sofia, Bulgaria
Research Site, Vina del MAr, Chile
Research Site, Kolin, Czech Republic
Research Site, Kyjov, Czech Republic
Research Site, Melnik, Czech Republic
Research Site, Praha 10, Czech Republic
Research Site, Praha 4, Czech Republic
Research Site, Praha 6, Czech Republic
Research Site, Argenteuil, France
Research Site, Clermont-ferrand, France
Research Site, Limoges, France
Research Site, Marseille, France
Research Site, Nantes, France
Research Site, Heidelberg, Germany
Research Site, Leipzig, Germany
Research Site, Athens, Greece
Research Site, Thessaloniki, Greece
Research Site, Ahmedabad, India
Research Site, Bangalore, India
Research Site, Hyderabad, India
Research Site, Lucknow, India
Research Site, New Delhi, India
Research Site, Holon, Israel
Research Site, Jerusalem, Israel
Research Site, Rehovot, Israel
Research Site, Rozzano, Italy
Research Site, Kaunas, Lithuania
Research Site, Klaipeda, Lithuania
Research Site, Klajpeda, Lithuania
Research Site, Bucharest, Romania
Research Site, Timisoara, Romania
Research Site, Moscow, Russian Federation
Research Site, Perm, Russian Federation
Research Site, Smolensk, Russian Federation
Research Site, Alicante, Spain
Research Site, Alzira (Valencia), Spain
Research Site, Barcelona, Spain
Research Site, Granollers, Spain
Research Site, Madrid, Spain
Research Site, Terrassa, Spain
Research Site, Bangkok, Thailand
Research Site, Songkla, Thailand
Research Site, Antalya, Turkey
Research Site, Trabzon, Turkey
Research Site, Chernivtsi, Ukraine
Research Site, Ivano-Frankivsk, Ukraine
Research Site, Odesa, Ukraine
Research Site, Poltava, Ukraine
Research Site, Zaporizhzhya, Ukraine
Research Site, Stanford, California, United States
Research Site, Torrance, California, United States
Research Site, Denver, Colorado, United States
Research Site, Boston, Massachusetts, United States
Research Site, Minneapolis, Minnesota, United States
Research Site, Greenfield Park, Quebec, Canada