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Clearance of Nasal Staphylococcus Aureus With Triple Antibiotic Ointment

Information source: Northwestern University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Nasal Carriers of Staphylococcus Aureus

Intervention: Neosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg) (Drug)

Phase: N/A

Status: Completed

Sponsored by: Northwestern University

Official(s) and/or principal investigator(s):
Peter Lio, MD, Principal Investigator, Affiliation: Northwestern Unviersity


Staphylococcus aureus, a bacteria that lives commonly in the anterior nostrils, is seen in about 30% of healthcare workers. Applying mupirocin ointment, a prescription, to the nostrils twice daily for 5 days is the current standard of care for treatment to clear this bacteria. This research study is designed to determine the rate of clearance of this bacteria in healthcare workers who are carriers when using triple antibiotic ointment instead of mupirocin ointment.

Clinical Details

Official title: Clearance of Nasal Staphylococcus Aureus Colonization With Triple Antibiotic Ointment

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome:

Carrier Rate for Staphylococcus Aureus

MSSA Clearance Rate

MRSA Clearance Rate


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Willing and able to give informed consent

- Must have consented prior to registration for the study

Exclusion Criteria:

- active infection

- concurrent treatment with antibiotics, topical or systemic

- S. aureus decolonization attempt in prior six months

- history of HIV

- chemotherapy or systemic immunosuppressive therapy

- history of neomycin allergy or sensitivity

Locations and Contacts

Northwestern University, Chicago, Illinois 60611, United States
Additional Information

Starting date: September 2009
Last updated: December 11, 2014

Page last updated: August 23, 2015

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