The Effect of Cataract Extraction on the Contractility of Ciliary Muscle
Information source: Samsung Medical Center
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Presbyopia; Cataract
Intervention: UBM with pilocarpine in presbyopia (Other)
Phase: N/A
Status: Enrolling by invitation
Sponsored by: Samsung Medical Center Official(s) and/or principal investigator(s):
Changwon Kee, M.D., Study Director, Affiliation: Department of Ophthalmology, Samsung Medical Center, Ilwon-dong, Kangnam-gu, Seoul, 135-710, Republic of Korea. E-mail: ckee@skku.edu
Summary
The purpose of this study is to investigate the changes in the pilocarpine-induced ciliary
body movement before and after cataract extraction in order to determine the effect of lens
sclerosis on the ciliary muscle contractility.
Clinical Details
Official title: The Effect of Cataract Extraction on the Contractility of Ciliary Muscle
Study design: Basic Science, Double Blind (Investigator, Outcomes Assessor), Uncontrolled, Single Group Assignment
Primary outcome: ultrasound biomicroscopic findings (ciliary body axial length)
Detailed description:
The functional changes in the ciliary body in presbyopia are not only important in a study of
the mechanism for presbyopia but are also a key to various procedures or devices used to
restore accommodation. Therefore, it is becoming increasingly important to quantify the in
vivo accommodative changes in the aging ciliary muscle with and without a lens. We are going
to evaluate the changes in the pilocarpine-induced contractility of the ciliary muscle in
eyes with presbyopia before and after cataract extraction using ultrasound biomicroscopy
(UBM).UBM will be performed with and without instilling 2 % pilocarpine, as well as before
and 2 months after cataract extraction. Images of the ciliary body will be compared visually
using Adobe Photoshop 7. 0.
Eligibility
Minimum age: 55 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age : same or more than 55 years
- Patients with senile cataract who are going to get cataract surgery
Exclusion Criteria:
- Age : less than 55 years
- Previous ocular disease other than cataract.
Locations and Contacts
Samsung Medical Center, Seoul 135-710, Korea, Republic of
Additional Information
Related publications: Stachs O, Martin H, Kirchhoff A, Stave J, Terwee T, Guthoff R. Monitoring accommodative ciliary muscle function using three-dimensional ultrasound. Graefes Arch Clin Exp Ophthalmol. 2002 Nov;240(11):906-12. Epub 2002 Oct 9.
Starting date: May 2006
Ending date: March 2008
Last updated: February 18, 2008
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