The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH)
Information source: Nationwide Children's Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cardiac Surgical Procedures
Intervention: Acute normovolemic hemodilution (ANH) (Procedure)
Phase: N/A
Status: Enrolling by invitation
Sponsored by: Aymen N Naguib
Summary
Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease
post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass. Blood
is drawn from our patients pre-bypass after obtaining the arterial line and administered
back to the patient after separation from cardiopulmonary bypass (CPB) and reversal of
heparin with protamine. In our practice we noticed some variability in the impact of ANH on
postoperative bleeding; with some patients appearing to show more hemostasis after
separation from CPB than others. This is a prospective study to find out if there is an
optimal time period that guarantees the largest amount of functioning platelets and what is
the best practice for drawing and storing of ANH to guarantee the largest amount of
functioning platelets.
Clinical Details
Study design: Observational Model: Case-Only, Time Perspective: Prospective
Primary outcome: Change in platelet count & function.
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- All patients undergoing cardiac surgery on CPB and are determined to be suitable for
ANH by the cardiac team during the huddle process per our standard protocol.
Exclusion Criteria:
- Patients who are undergoing cardiac surgery on CPB who are determined not to be
suitable candidates for ANH by the cardiac team during the huddle process per our
standard protocol.
Locations and Contacts
Nationwide Children's Hospital, Columbus, Ohio 43205, United States
Additional Information
Starting date: March 2014
Last updated: May 6, 2015
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