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The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH)

Information source: Nationwide Children's Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Cardiac Surgical Procedures

Intervention: Acute normovolemic hemodilution (ANH) (Procedure)

Phase: N/A

Status: Enrolling by invitation

Sponsored by: Aymen N Naguib

Summary

Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass. Blood is drawn from our patients pre-bypass after obtaining the arterial line and administered back to the patient after separation from cardiopulmonary bypass (CPB) and reversal of heparin with protamine. In our practice we noticed some variability in the impact of ANH on postoperative bleeding; with some patients appearing to show more hemostasis after separation from CPB than others. This is a prospective study to find out if there is an optimal time period that guarantees the largest amount of functioning platelets and what is the best practice for drawing and storing of ANH to guarantee the largest amount of functioning platelets.

Clinical Details

Study design: Observational Model: Case-Only, Time Perspective: Prospective

Primary outcome: Change in platelet count & function.

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- All patients undergoing cardiac surgery on CPB and are determined to be suitable for

ANH by the cardiac team during the huddle process per our standard protocol. Exclusion Criteria:

- Patients who are undergoing cardiac surgery on CPB who are determined not to be

suitable candidates for ANH by the cardiac team during the huddle process per our standard protocol.

Locations and Contacts

Nationwide Children's Hospital, Columbus, Ohio 43205, United States
Additional Information

Starting date: March 2014
Last updated: May 6, 2015

Page last updated: August 23, 2015

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