DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Application of Contrast Enhance Ultrasound to Evaluate Hemodynamics Change in MCA With Moderate to Severe Stenosis

Information source: Capital Medical University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Stenosis

Intervention: atorvastatin (Drug)

Phase: Phase 1/Phase 2

Status: Recruiting

Sponsored by: Capital Medical University

Official(s) and/or principal investigator(s):
Zhong Qin, master, Study Director, Affiliation: science study Dept

Overall contact:
Xu Bin, master, Phone: 86-010-88062285, Email: xubincj1992@yahoo.com.cn

Summary

Objective: To monitor and evaluate the change of intracranial hemodynamics and MCA stenosis after 24-week atorvastatin treatment using CEUS, CTA and DSA. Study design: Total 30 patients (60 arteries) will be enrolled in this study, who had MCA infarction within 6 months prior to screening, and has not received any statins treatment before stroke. Eligible patient will receive atorvastatin 40mg treatment for 24 weeks. Hemodynamics changes and MCA stenosis will be evaluated using CEUS at baseline, 3-month,and 6-month. MCA stenosis, bloodstream velocity, as well as clinical symptoms will be assessed at each visit and compared to baseline.

Clinical Details

Official title: Application of Contrast Enhance Ultrasound to Evaluate Hemodynamics Change in MCA With Moderate to Severe Stenosis After 24-week Atorvastatin Treatment

Study design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Hemodynamics changes and MCA stenosis

Detailed description: The cerebral infarction resulted from medially and heavily narrow MCA is determined by the three-type screen method .For the first screen cerebral infarction patients of MCA area who has the stroke or TIA history In 6 months are determined by the clinic stroke measure table,transstadial Doppler ultrasonography (TCD) carotid ultrasonography and skull CT. For the second the MAC area infarction and vessel narrow are determined by the skull magnetic resonance (MRI) and magnetic resonance vessel imaging (MRA) and the MCA trend bloodstream dynamics feature and narrow extent Are observed by the strengthened ultrasonography (CEVS) For the third, The MCA narrow extent is measured by the DSA test which is currently regarded as a gold standard and /or by the CTA .The atorvastatin 20mg Treatment is given to the patients who all use the antiplatelet medicine The clinic symptom improvement MCA narrow extent and bloodstream velocity are dynamically observed visited and analysed respectively at the basic line 3 and 6 months after treatment

Eligibility

Minimum age: 40 Years. Maximum age: 90 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients who had MCA infarction of unilateral with moderate to severe stenosis within

6 months prior to screening, and has not received any statins treatment before stroke. Exclusion Criteria:

- With side of extracranial carotid artery 70-100% severe narrow or block

- Vertebrobasilar artery lesions caused by cerebral infarction

- Have rheumatic heart disease, the atrial fibrillation of heart disease, those who

Cerebral hemorrhage patients

- Serious liver and kidney function is not complete patients.

Locations and Contacts

Xu Bin, master, Phone: 86-010-88062285, Email: xubincj1992@yahoo.com.cn

FuXing Hospital,Capital Medicial University, Beijing 100038, China; Recruiting
Xu Bin, master, Phone: 86-010-88062285, Email: xubincj1992@yahoo.com.cn
Xu Bin, master, Principal Investigator
Additional Information

Starting date: January 2012
Last updated: June 11, 2012

Page last updated: August 20, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017