Anesthesia for Dental Treatment in Cardiac Patients: Lidocaine Comparative Study

Condition(s) targeted: Arrhythmias; Anxiety

Phase: N/A

Status: Completed

Sponsored by: University of Sao Paulo

Official(s) and/or principal investigator(s):
Joaquim E Vieira, MD, PhD, Principal Investigator, Affiliation: University of Sao Paulo Medical School - FMUSP

Prospective, randomized double-blinded study to investigate hemodynamic changes in valvular cardiac patients during dental treatment with the use of a local anesthesia containing epinephrine.

Official title: Loco Regional Anesthesia for Dental Treatment in Cardiac Patients: Comparative Study Between Plain Lidocaine 2% and Lidocaine 2% With Epinephrine 1:100.000

Study design: Case Control, Prospective

Primary outcome: arrhythmias

Secondary outcome:

Arterial pressure

anxiety

Detailed description: Patients with valvular disease constitute a group in which local anesthesia must be effective to avoid higher release of endogenous catecholamines that could trigger hemodynamic. The study was conducted in the Dental Department of the Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (Brazil). Patients were allocated into two groups through an aleatory numbered table: PL (plain 2% lidocaine, n= 31) and LE (2% lidocaine with 1: 100. 000 epinephrine, n= 28). The anesthetic amount was registered. DIXTAL monitor (São Paulo- Brazil) captured blood pressure, heart rate, oxygenation and electrocardiogram records.

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients with acquired valvular disease

Exclusion Criteria:

- Patients having platelets counting lower than 70. 000 or INR > 3

Hospital das Clínicas da FMUSP, Sao Paulo 05430 010, Brazil

Starting date: January 2003
Ending date: July 2005
Last updated: April 30, 2008