Anesthesia for Dental Treatment in Cardiac Patients: Lidocaine Comparative Study
Information source: University of Sao Paulo
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Arrhythmias; Anxiety
Sponsored by: University of Sao Paulo
Official(s) and/or principal investigator(s):
Joaquim E Vieira, MD, PhD, Principal Investigator, Affiliation: University of Sao Paulo Medical School - FMUSP
Prospective, randomized double-blinded study to investigate hemodynamic changes in valvular
cardiac patients during dental treatment with the use of a local anesthesia containing
Official title: Loco Regional Anesthesia for Dental Treatment in Cardiac Patients: Comparative Study Between Plain Lidocaine 2% and Lidocaine 2% With Epinephrine 1:100.000
Study design: Case Control, Prospective
Primary outcome: arrhythmias
Patients with valvular disease constitute a group in which local anesthesia must be effective
to avoid higher release of endogenous catecholamines that could trigger hemodynamic. The
study was conducted in the Dental Department of the Instituto do Coração do Hospital das
Clínicas da Faculdade de Medicina da Universidade de São Paulo (Brazil). Patients were
allocated into two groups through an aleatory numbered table: PL (plain 2% lidocaine, n= 31)
and LE (2% lidocaine with 1: 100. 000 epinephrine, n= 28). The anesthetic amount was
registered. DIXTAL monitor (São Paulo- Brazil) captured blood pressure, heart rate,
oxygenation and electrocardiogram records.
Minimum age: 18 Years.
Maximum age: 65 Years.
- Patients with acquired valvular disease
- Patients having platelets counting lower than 70. 000 or INR > 3
Locations and Contacts
Hospital das ClÃnicas da FMUSP, Sao Paulo 05430 010, Brazil
Starting date: January 2003
Ending date: July 2005
Last updated: April 30, 2008