Capsaicin on Salty Gustatory Cortices
Information source: Third Military Medical University
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Healthy Volunteer
Intervention: Capsaicin (Dietary Supplement)
Phase: Phase 4
Status: Completed
Sponsored by: Zhiming Zhu
Summary
Excess dietary salt intake is closely associated with the development of hypertension and
cardiocerebral vascular diseases. Preference of high salt diet might involve salty gustatory
cortices change. This study focuses on examining the neuroimaging changes of salty gustatory
cortices under different concentration of NaCl solution with or without capsaicin
intervention through brain PET/CT scan.
Clinical Details
Official title: Effects of Capsaicin on Salty Gustatory Cortices in Human
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
Primary outcome: Neuroimaging changes of salty gustatory cortices
Detailed description:
Hypertension and its related complications are common health problems that can lead to
multiple organ damage and death. Excessive salt intake plays an important role in the
development of hypertension.
The experimental design is a randomized, double-blind, interventional study to investigate
the neuroimaging changes of salty gustatory cortices under different concentration of NaCl
solution with or without capsaicin intervention through brain PET/CT scan.
Eligibility
Minimum age: 18 Years.
Maximum age: 55 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age ≥ 18 years and ≤ 55 years.
- Willing and able to provide written informed consent.
- Willing and able to comply with all study procedures.
Exclusion Criteria:
- Diabetes.
- Hypertension.
- High basic metabolic rate, tumor, epilepsia.
- Hypogeusia or loss due to neural system disease or oral and digestive disease.
- Capsaicin allergy and poor compliance.
- Recently oral diuretics and participate in other pharmacological experiment in 3
months.
- Acute infection, cancer, serious arrhythmias, drug or alcohol abuse.
- Currently have cold, fever, acidosis, dehydration, diarrhea, vomiting during the
study.
- Unwilling or unable to communication due to the dysnoesia and language disorders.
- Severe neural or psychiatric diseases that would preclude fully understand and
corporation in the study.
- History of allergic reaction attributed to 18F-FDG.
- Pregnancy or lactation.
Locations and Contacts
Daping Hospital, The Third Military Medical University, Chongqing, Chongqing 400042, China
Additional Information
Starting date: May 2013
Last updated: December 15, 2013
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