This randomized phase III trial studies enzalutamide to see how well it works compared to
enzalutamide, abiraterone, and prednisone in treating patients with castration-resistant
metastatic prostate cancer. Androgens can cause the growth of prostate cancer cells. Drugs,
such as enzalutamide, abiraterone acetate, and prednisone, may lessen the amount of
androgens made by the body.
- To assess the grade 3 or higher toxicity profile and compare safety by treatment
- To assess and compare post-treatment prostate-specific antigen (PSA) declines by
- To compare radiographic progression free survival defined by Prostate Cancer
Working Group 2 (PCWG2), and objective response rate, by treatment arm.
- To test for radiographic progression free survival (rPFS) treatment interaction in
- To assess pre- and post-treatment measures of tumor burden and bone activity using
sodium fluoride (NaF) positron emission tomography (PET)/computed tomography (CT)
and technetium (Tc) methylene diphosphonate (MDP) bone scintigraphy and correlate
these measures with overall survival.
- To develop and validate prognostic and predictive models of overall survival that
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Male.
UC San Diego Moores Cancer Center, La Jolla, California 92093, United States; Recruiting
James Randall, M.D., Phone: 858-822-6185
UCSF - Mount Zion, San Francisco, California 94115, United States; Recruiting
Terence Friedlander, M.D., Phone: 415-514-8481
The Shaw Regional Cancer Center, Edwards, Colorado 81632, United States; Recruiting
Alexander Urquhart, M.D., Phone: 970-569-7684
Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, United States; Recruiting
Philip Stella, M.D., Phone: 734-712-4931
Mount Sinai Medical Center CCOP, Miami Beach, Florida 33140, United States; Recruiting
Michael Schwartz, M.D., Phone: 305-674-2625
Sacred Heart Hospital, Pensacola, Florida 32504, United States; Recruiting
James Watkins, M.D., Phone: 850-416-6933
Sacred Heart Medical Oncology Group - Davis Highway, Pensacola, Florida 32514, United States; Recruiting
James Watkins, M.D., Phone: 850-416-6933
Illinois Cancer Care - Peoria, Peoria, Illinois 61615, United States; Recruiting
Nguyet Le-Lindqwister, M.D., Phone: 309-672-5681
Quincy Medical Group - Clinic, Quincy, Illinois 62301, United States; Recruiting
Raymond Smith, M.D., Phone: 217-277-3500
Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana 46545, United States; Recruiting
Robin Zon, M.D., Phone: 574-647-6343
Michiana Hematology Oncology-PC Westville, Westville, Indiana 46391, United States; Recruiting
Robin Zon, Phone: 574-647-6343
Hematology Oncology Associates - Quad Cities, Bettendorf, Iowa 52722, United States; Recruiting
Shobha Chitneni, M.D., Phone: 563-355-7733
Genesis Medical Center - East Campus, Davenport, Iowa 52803, United States; Recruiting
George Kovach, M.D., Phone: 563-421-1960
University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, United States; Recruiting
Daniel Vaena, M.D., Phone: 319-356-3944
VA Medical Center - University of Iowa, Iowa City, Iowa 52246, United States; Recruiting
Daniel Vaena, M.D., Phone: 319-356-3944
Harold Alfond Center for Cancer Care, Augusta, Maine 04330, United States; Recruiting
Thomas H. Openshaw, M.D., Phone: 207-621-6100
Eastern Maine Medical Center, Bangor, Maine 04401, United States; Recruiting
Thomas Openshaw, M.D., Phone: 207-973-7474
Frederick Memorial Hospital, Frederick, Maryland 21701, United States; Recruiting
Elhamy Eskander, M.D., Phone: 301-662-8477
Saint Joseph Mercy Hospital, Ann Arbor, Michigan 48106, United States; Recruiting
Philip J. Stella, Phone: 734-712-5947
Henry Ford Hospital, Detroit, Michigan 48202, United States; Recruiting
Robert Chapman, M.D., Phone: 313-916-1784
Green Bay Oncology - Escanaba, Escanaba, Michigan 49431, United States; Recruiting
Anthony J. Jaslowski, Phone: 610-402-2273
Green Bay Oncology - Iron Mountain, Iron Mountain, Michigan 49801, United States; Recruiting
Anthony J. Jaslowski, Phone: 610-402-2273
Saint Mary Mercy Hospital, Livonia, Michigan 48154, United States; Recruiting
Philip J. Stella, Phone: 610-402-2273
Saint Mary's of Michigan, Saginaw, Michigan 48601, United States; Recruiting
Philip J. Stella, Phone: 610-402-2273
Mercy Hospital, Coon Rapids, Minnesota 55433, United States; Recruiting
Daniel Anderson, M.D., Phone: 952-993-1517
Essentia Health Duluth Clinic CCOP, Duluth, Minnesota 55805, United States; Recruiting
Bret Friday, M.D., Phone: 218-786-3625
Minneapolis Veterans Medical Center, Minneapolis, Minnesota 55417, United States; Recruiting
Sharon Luikart, MD, Phone: 612-467-4134
Park Nicollet Cancer Center, Saint Louis Park, Minnesota 55416, United States; Recruiting
Daniel M. Anderson, Phone: 952-993-3248
Saint Francis Regional Medical Center, Shakopee, Minnesota 55379, United States; Recruiting
Daniel Anderson, M.D., Phone: 952-993-1517
Lakeview Hospital, Stillwater, Minnesota 55082, United States; Recruiting
Daniel M. Anderson, Phone: 651-439-1517
Saint Francis Medical Center, Cape Giradeau, Missouri 63703, United States; Recruiting
James Wade, M.D., Phone: 217-876-6600
Saint Luke's Hospital, Chesterfield, Missouri 63017, United States; Recruiting
Donald Busiek, M.D., Phone: 314-205-6737
University of Missouri - Ellis Fischel, Columbia, Missouri 65203, United States; Recruiting
Donald Doll, M.D., Phone: 573-882-6964
Missouri Baptist Medical Center, Saint Louis, Missouri 63131, United States; Recruiting
Alan P. Lyss, Phone: 610-402-2273
Washington University School of Medicine, Saint Louis, Missouri 63110, United States; Recruiting
Joel Picus, M.D., Phone: 314-362-5740
Mercy Hospital - Springfield, Springfield, Missouri 65804, United States; Recruiting
Jay Carlson, M.D., Phone: 417-820-3554
Saint Vincent Healthcare, Billings, Montana 59101, United States; Recruiting
Benjamin Marchello, M.D., Phone: 406-238-6290
Bozeman Deaconess Cancer Center, Bozeman, Montana 59715, United States; Recruiting
Benjamin T. Marchello, MD, Phone: 406-238-6290
Nebraska Methodist Hospital, Omaha, Nebraska 68114, United States; Recruiting
Ralph Hauke, M.D., Phone: 402-991-8070
HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas, Nevada 89113, United States; Recruiting
John Ellerton, M.D., Phone: 702-822-2000
HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas, Nevada 89128, United States; Recruiting
John Ellerton, M.D., Phone: 702-822-2000
New Hampshire Oncology - Hematology PA, Concord, New Hampshire 03301, United States; Recruiting
Frederick Briccetti, M.D., Phone: 603-552-9170
Wentworth Douglass Hospital, Dover, New Hampshire 03820, United States; Recruiting
Taylor Ortiz, M.D., Phone: 603-742-8787
New Hampshire Oncology Hematology Associates, Hooksett, New Hampshire 03106, United States; Recruiting
Frederick Briccetti, M.D., Phone: 603-552-9170
LRGHealthcare-Lakes Region General Hospital, Laconia, New Hampshire 03246, United States; Recruiting
Frederick Briccetti, M.D., Phone: 603-552-9170
University of New Mexico, Albuquerque, New Mexico 87106, United States; Recruiting
Richard Lauer, M.D., Phone: 505-925-0478
Memorial Medical Center-Las Cruces, Las Cruces, New Mexico 88011, United States; Recruiting
Richard Lauer, M.D., Phone: 505-925-0478
Christus Saint Vincent Regional Cancer Center, Santa Fe, New Mexico 87505, United States; Recruiting
Richard Lauer, M.D., Phone: 505-925-0478
Maimonides Medical Center, Brooklyn, New York 11219, United States; Recruiting
Kevin Becker, M.D., Phone: 718-765-2600
Memorial Sloan-Kettering Cancer Center, New York, New York 10021, United States; Recruiting
Michael J. Morris, Phone: 212-639-2000
Randolph Hospital, Asheboro, North Carolina 27203, United States; Recruiting
James Granfortuna, M.D., Phone: 336-832-1100
Core Health Cancer Center, Greensboro, North Carolina 27403, United States; Recruiting
James Granfortuna, M.D., Phone: 336-832-1100
Annie Penn Memorial Hospital, Reidsville, North Carolina 27320, United States; Recruiting
James Granfortuna, M.D., Phone: 336-832-1100
Marion L. Shepard Cancer Center at Beaufort County Hospital, Washington, North Carolina 27889, United States; Recruiting
John J. Inzerillo, Phone: 252-975-4308
Sanford Bismarck Medical Center, Bismarck, North Dakota 58501, United States; Recruiting
Preston Steen, M.D., Phone: 701-234-6161
Sanford Clinic North-Fargo, Fargo, North Dakota 58102, United States; Recruiting
Preston Steen, M.D., Phone: 701-234-6161
Sanford Medical Center-Fargo, Fargo, North Dakota 58122, United States; Recruiting
Preston Steen, M.D., Phone: 701-234-6161
Case Western Reserve University, Cleveland, Ohio 44106, United States; Recruiting
Matthew Cooney, M.D., Phone: 216-844-7048
Cleveland Clinic Foundation, Cleveland, Ohio 44195, United States; Recruiting
Anjali Advani, M.D., Phone: 216-445-9354
Cancer Centers of Southwest Oklahoma, LLC - Lawton, Lawton, Oklahoma 73505, United States; Recruiting
Nadim F. Nimeh, MD, Phone: 580-536-2121, Ext: 113
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States; Recruiting
Sindhu Singh, M.D., Phone: 405-271-8777
Good Samaritan Hospital, Corvallis, Oregon 97330, United States; Recruiting
Kimberly McGregor, M.D., Phone: 541-768-4771
Kaiser Permanente Health Care - Portland, Portland, Oregon 97232, United States; Recruiting
Nagendra Tirumali, MD, Phone: 503-331-6500
Adams Cancer Center, Gettysburg, Pennsylvania 17325, United States; Recruiting
Amir Tabatabai, M.D., Phone: 717-741-8124
WellSpan Health-York Hospital, York, Pennsylvania 17405, United States; Recruiting
Amir Tabatabai, M.D., Phone: 717-741-9229
Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota 57104, United States; Recruiting
Miroslaw Mazurczak, Phone: 605-328-8000
Virginia Commonwealth University, Richmond, Virginia 23298, United States; Recruiting
Craig Swainey, M.D., Phone: 804-828-9723
PeaceHealth Saint Joseph Medical Center, Bellingham, Washington 98225, United States; Recruiting
Gary Goodman, M.D., Phone: 206-386-2122
Harrison Health Partners Hematology and Oncology - Poulsbo, Poulsbo, Washington 98370, United States; Recruiting
Gary Goodman, M.D., Phone: 206-386-2122
Saint Mary's Medical Center, Huntington, West Virginia 25702, United States; Recruiting
Arvinder Bir, M.D., Phone: 304-528-4658
Green Bay Oncology at Saint Vincent Hospital, Green Bay, Wisconsin 54301-3526, United States; Recruiting
Anthony J. Jaslowski, Phone: 610-402-2273
Saint Mary's Hospital, Green Bay, Wisconsin 54303, United States; Recruiting
Anthony J. Jaslowski, Phone: 610-402-2273
Saint Vincent Hospital, Green Bay, Wisconsin 54301, United States; Recruiting
Anthony Jaslowski, M.D., Phone: 920-884-3135
Holy Family Memorial Hospital, Manitowoc, Wisconsin 54221, United States; Recruiting
Anthony J. Jaslowski, Phone: 610-402-2273
Marshfield Clinic, Marshfield, Wisconsin 54449, United States; Recruiting
Seth Fagbemi, M.D., Phone: 715-387-5426
Saint Joseph's Hospital, Marshfield, Wisconsin 54449, United States; Recruiting
Seth O. Fagbemi, MD, Phone: 715-387-5426
Green Bay Oncology - Oconto Falls, Oconto Falls, Wisconsin 54154, United States; Recruiting
Anthony J. Jaslowski, Phone: 610-402-2273
Saint Nicholas Hospital, Sheboygan, Wisconsin 53081, United States; Recruiting
Anthony Jaslowski, M.D., Phone: 920-884-3135
Marshfield Clinic at Saint Michael's Hospital, Stevens Point, Wisconsin 54481, United States; Recruiting
Seth O. Fagbemi, MD, Phone: 715-387-5426
Saint Michael's Hospital Cancer Center, Stevens Point, Wisconsin 54481, United States; Recruiting
Seth O. Fagbemi, MD, Phone: 715-387-5426
Green Bay Oncology - Sturgeon Bay, Sturgeon Bay, Wisconsin 54235, United States; Recruiting
Anthony J. Jaslowski, Phone: 610-402-2273
Diagnostic and Treatment Center, Weston, Wisconsin 54476, United States; Recruiting
Seth Fagbemi, M.D., Phone: 715-387-5426
Marshfield Clinic - Weston Center, Weston, Wisconsin 54476, United States; Recruiting
Seth Fagbemi, M.D., Phone: 715-387-5426