Single Dose of Etomidate and Adrenal Cortex
Information source: Istanbul University
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Adrenocortical Deficiency; Hemodynamic Instability
Intervention: Etomidate (Drug); Midazolam (Drug); methylprednisolone (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Istanbul University Official(s) and/or principal investigator(s): Fatis Altindas, Prof., Study Director, Affiliation: Chairman of the Department of Anesthesiology
Summary
we aim to evaluate the effects of single dose of etomidate or use of steroid prior to
etomidate during emergency intubation on hemodynamics and adrenal cortex.
Clinical Details
Official title: the Effect of Single Dose of Etomidate Used During Emergency Intubation on Hemodynamics and Adrenal Cortex: a Randomized Clinical Trial
Study design: Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Prevention
Primary outcome: effect of use of steroid on adrenal cortex prior to single dose etomidate by comparing cortisol levels
Secondary outcome: compare effects of midazolam and etomidate on systemic blood pressure
Eligibility
Minimum age: 25 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients between 25-65 years old with American Society of Anesthesiology scores III
or IV that have applied to emergency department and receives an indication for
intubation by the intensive care unit physicians will be included to the study
Exclusion Criteria:
- Patients using steroid prior to the intubation and/or patients with chronical
inflammatory diseases will be excluded from the study.
Locations and Contacts
Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department, Istanbul, Fatih 34400, Turkey
Additional Information
Related publications: Tekwani KL, Watts HF, Sweis RT, Rzechula KH, Kulstad EB. A comparison of the effects of etomidate and midazolam on hospital length of stay in patients with suspected sepsis: a prospective, randomized study. Ann Emerg Med. 2010 Nov;56(5):481-9. doi: 10.1016/j.annemergmed.2010.05.034. Epub 2010 Sep 15.
Starting date: December 2012
Last updated: August 23, 2013
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